{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:15:31Z","timestamp":1768457731575,"version":"3.49.0"},"reference-count":88,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008131","name":"Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn","doi-asserted-by":"publisher","award":["O\u2010105.0071"],"award-info":[{"award-number":["O\u2010105.0071"]}],"id":[{"id":"10.13039\/501100008131","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epigallocatechin\u20103\u2010gallate (EGCG) has been proven effective in treating viral warts. Since anticarcinogenic as well as anti\u2010inflammatory properties are ascribed to the substance, its use has been evaluated in the context of different dermatoses. The effect of EGCG on interface dermatitis (ID), however, has not yet been explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In this study, we investigated the effect of EGCG on an epidermal human <jats:italic>in\u2009vitro<\/jats:italic> model of ID.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Via immunohistochemistry, lesional skin of lichen planus patients and healthy skin were analysed concerning the intensity of interferon\u2010associated mediators, CXCL10 and MxA. Epidermal equivalents were stained analogously upon ID\u2010like stimulation and EGCG treatment. Monolayer keratinocytes were treated likewise and supernatants were analysed via ELISA while cells were processed for vitality assay or transcriptomic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CXCL10 and MxA are strongly expressed in lichen planus lesions and induced in keratinocytes upon ID\u2010like stimulation. EGCG reduces CXCL10 and MxA staining intensity in epidermis equivalents and CXCL10 secretion by keratinocytes upon stimulation. It furthermore minimizes the cytotoxic effect of the stimulus and downregulates a magnitude of typical pro\u2010inflammatory cytokines that are crucial for the perpetuation of ID.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We provide evidence concerning anti\u2010inflammatory effects of EGCG within a human <jats:italic>in\u2009vitro<\/jats:italic> model of ID. The capacity to suppress mediators that are centrally involved in disease perpetuation suggests EGCG as a potential topical therapeutic in lichen planus and other autoimmune skin diseases associated with ID.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17710","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T10:51:44Z","timestamp":1632912704000},"page":"144-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Epigallocatechin\u20103\u2010gallate exhibits anti\u2010inflammatory effects in a human interface dermatitis model\u2014implications for therapy"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0496-9041","authenticated-orcid":false,"given":"C.","family":"Braegelmann","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Niebel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ferring\u2010Schmitt","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Fetter","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Landsberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"H\u00f6lzel","sequence":"additional","affiliation":[{"name":"Institute of Experimental Oncology (IEO) University Hospital Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Effern","sequence":"additional","affiliation":[{"name":"Institute of Experimental Oncology (IEO) University Hospital Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Glodde","sequence":"additional","affiliation":[{"name":"Institute of Experimental Oncology (IEO) University Hospital Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Steinbuch","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Bieber","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.02.034"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.027151"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.96"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.42"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16464"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/817481"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-018-0696-y"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17186633"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.03.012"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12885"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31025"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06784.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2004.11.005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63649-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.251"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.622511"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.07.064"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62136-2"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6809"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1325-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00585.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S165966"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.04.002"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0262-4"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.10.075"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b15-00331"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/612593"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15122882"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav7561"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.01.031"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00344"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218690"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02847"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1721"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/43.1.7822763"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-012-0440-z"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.47.402"},{"key":"e_1_2_6_39_1","first-page":"e05239","article-title":"Scientific opinion on the safety of green tea catechins","volume":"16","author":"Younes M","year":"2018","journal-title":"EFSA J"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.58.5.0004"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6670"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0029-z"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01636"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.03.018"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700945"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213197"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2006.26.133"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.244"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.1"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.11.016"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0071-y"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.551"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.38"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(01)00057-6"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12014.x"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-073119-095439"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.402"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1423"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2012.04.023"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186825"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R116.774562"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01176"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912196"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm909"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1604"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0466-2"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0603252"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14226"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.09.016"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.017756"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.11.6592"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.269"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08137.x"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002876"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(03)00031-8"},{"key":"e_1_2_6_76_1","first-page":"82","article-title":"Pathological role of fractalkine\/CX3CL1 in rheumatic diseases: a unique chemokine with multiple functions","volume":"2","author":"Jones B","year":"2011","journal-title":"Front Immunol"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.12.6173"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1124\/mi.10.5.3"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.2147\/ITT.S277991"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13946"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/cia2.12092"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0261-x"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2012.121029"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1995.15"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13087"},{"key":"e_1_2_6_86_1","first-page":"34","article-title":"VCAM1 and ICAM1 expression in oral lichen planus","volume":"2","author":"Seyedmajidi M","year":"2013","journal-title":"Int J Mol Cell Med"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13419"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.10.011"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-008-8031-x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.17710","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.17710","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.17710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:31:19Z","timestamp":1693211479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.17710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,12]]},"references-count":88,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/jdv.17710"],"URL":"https:\/\/doi.org\/10.1111\/jdv.17710","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,12]]},"assertion":[{"value":"2021-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}