{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:09:55Z","timestamp":1787015395502,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Exposome aggressions are known to weaken certain skin functions, such as skin barrier and skin defense functions. Vichy volcanic mineralizing water (VVMW) percolates through volcanic and magmatic rocks in the Auvergne region in France to create a pure, highly mineralized water containing 15 minerals for a total mineral concentration of 5.2\u2009g\/L. Here, we provide an overview of the main results of\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    and\n                    <jats:italic>ex\u00a0vivo<\/jats:italic>\n                    studies (keratinocyte cultures, 3D reconstructed skin model, skin explants) and clinical studies to evaluate the effect of VVMW on key skin functions to help elucidate how it counteracts exposome aggressions on the skin. Properties to strengthen the skin barrier: VVMW stimulated the synthesis of tight junction proteins and keratinocyte differentiation markers\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    . In clinical studies, VVMW accelerated cell turnover and improved skin hydration. Properties to strengthen skin antioxidant defense: VVMW stimulated the expression of antioxidant defense markers and had a higher stimulatory effect than a competitor thermal water on the expression of superoxide dismutase, catalase, and glutathione peroxidase in keratinocytes\n                    <jats:italic>in\u00a0vitro. In vivo<\/jats:italic>\n                    , VVMW restored endogenous catalase activity after exposure to UVA radiation. Anti\u2010inflammatory action: VVMW reduced substance P\u2010induced inflammation\n                    <jats:italic>ex\u00a0vivo<\/jats:italic>\n                    and lactic acid\u2010induced stinging\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    . Topical application of VVMW in subjects with sensitive skin showed soothing and decongestant effects by reducing skin dryness and erythema. After sodium lauryl sulfate \u2010induced skin barrier disruption, recovery from redness and erythema was faster following application of VVMW compared to a competitor water or untreated skin. These studies illustrate that VVMW has unique properties to repair and regenerate the skin barrier, as well as to strengthen antioxidant and immune defenses, which help protect the skin against exposome aggressions.\n                  <\/jats:p>","DOI":"10.1111\/jdv.17784","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T17:59:17Z","timestamp":1641232757000},"page":"5-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vichy volcanic mineralizing water has unique properties to strengthen the skin barrier and skin defenses against exposome aggressions"],"prefix":"10.1111","volume":"36","author":[{"given":"V.","family":"Rasmont","sequence":"first","affiliation":[{"name":"Laboratoires Vichy Levallois Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Valois","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research &amp; Innovation Chevilly Larue France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gueniche","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research &amp; Innovation Chevilly Larue France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sore","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research &amp; Innovation Chevilly Larue France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kerob","sequence":"additional","affiliation":[{"name":"Laboratoires Vichy Levallois Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Laboratoires Vichy Levallois Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3423-5038","authenticated-orcid":false,"given":"E.","family":"Berardesca","sequence":"additional","affiliation":[{"name":"Phillip Frost Department of Dermatology University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3406\/racf.1982.2347"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0025727300070976"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.09.015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16614"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/eem.12.34"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.406"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2013.54.2.523"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2013.03.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.125310"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.21819"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-1995.193174"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.1996.tb00158.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2007.00291.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2009.00432.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S157849"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03893.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.3.324"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S213594"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12470"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200202116"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0503"},{"key":"e_1_2_10_23_1","unstructured":"NielsenMRV ValoisA SoreG GuenicheA FagotD.Vichy volcanic mineralising water stimulates epidermal keratinocyte differentiation and tight junction protein synthesis: Results of anin\u00a0vitrostudy European Academy of Dermatology and Venereology 29th Congress; 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