{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:15:02Z","timestamp":1787616902143,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In JADE COMPARE, abrocitinib improved severity of atopic dermatitis (AD) and demonstrated rapid itch relief.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We examined clinically meaningful improvements in selected patient\u2010reported outcomes (PROs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>JADE COMPARE was a multicentre, phase 3 randomized, double\u2010blind, placebo\u2010controlled trial. Adults with moderate\u2010to\u2010severe AD were randomized 2:2:2:1 to receive 16\u2009weeks of oral abrocitinib 200 or 100\u2009mg once daily, dupilumab 300\u2009mg subcutaneous injection every 2\u2009weeks, or placebo, with background topical therapy. PROs included Dermatology Life Quality Index (DLQI), Patient\u2010Oriented Eczema Measure (POEM), Night Time Itch Scale (NTIS), Pruritus and Symptoms Assessment for Atopic Dermatitis, Patient Global Assessment, SCORing Atopic Dermatitis, and Hospital Anxiety and Depression Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At week 16, the proportion of patients achieving POEM scores &lt;3 was 21.3% and 11.7% for 200 and 100\u2009mg abrocitinib, 12.4% for dupilumab, and 4.8% for placebo (vs. abrocitinib, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 and <jats:italic>P<\/jats:italic>\u2009=\u20090.04). Proportion achieving \u22654\u2010point improvement from baseline in NTIS severity was 64.3% and 52.4% for 200 and 100\u2009mg abrocitinib, 54.0% for dupilumab, and 34.4% for placebo (vs. abrocitinib, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 and <jats:italic>P<\/jats:italic>\u2009=\u20090.007). Proportion achieving \u22654\u2010point improvement from baseline in DLQI was 85.0% and 74.4% for 200 and 100\u2009mg abrocitinib, 83.4% for dupilumab, and 59.7% for placebo (vs. abrocitinib, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 and <jats:italic>P<\/jats:italic>\u2009=\u20090.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Significant improvements in PROs were demonstrated with both abrocitinib doses vs. placebo, and abrocitinib 200\u2009mg provided numerically greater effects compared with dupilumab in patients with moderate\u2010to\u2010severe AD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17813","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T09:10:12Z","timestamp":1636967412000},"page":"434-443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Patient\u2010reported outcomes from the JADE COMPARE randomized phase 3 study of abrocitinib in adults with moderate\u2010to\u2010severe atopic dermatitis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-1743","authenticated-orcid":false,"given":"J.P.","family":"Thyssen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Yosipovitch","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Itch Center University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Paul","sequence":"additional","affiliation":[{"name":"Toulouse University and CHU Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3736-1515","authenticated-orcid":false,"given":"S.G.","family":"Kwatra","sequence":"additional","affiliation":[{"name":"Department of Dermatology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9370-3279","authenticated-orcid":false,"given":"C.\u2010Y.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"DiBonaventura","sequence":"additional","affiliation":[{"name":"Pfizer Inc. 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