{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T14:32:53Z","timestamp":1771684373863,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The association between vitiligo and hearing loss has been noted but the specific frequencies and degrees of hearing impairment remain unclear. The objective of this systematic review was to investigate the relationship between vitiligo and hearing thresholds at various specific frequencies. We followed the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) guidelines. We searched MEDLINE and Embase for relevant studies from inception to 10th April 2021. Case\u2010control studies, cross\u2010sectional, or cohort studies that compared the frequency\u2010specific hearing thresholds between vitiligo patients and age\u2010matched non\u2010vitiligo controls were included. There were neither language nor geographic limitations. We used the Newcastle\u2010Ottawa Scale to assess the risk of bias of included studies. The DerSimonian and Laird random\u2010effects model was utilized in meta\u2010analyses due to expected clinical heterogeneity. We included 9 case\u2010control studies with 371 vitiligo patients and 349 controls, which were rated with low or unclear risk. We found neither relevant cross\u2010sectional nor cohort studies. The meta\u2010analysis showed that when compared with controls, vitiligo patients had significantly higher pure\u2010tone hearing thresholds at 2000, 4000, and 8000\u2009Hz. In conclusions, vitiligo patients are prone to high\u2010frequency sensorineural hearing loss.<\/jats:p>","DOI":"10.1111\/jdv.17815","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T09:12:08Z","timestamp":1636967528000},"page":"373-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association of vitiligo with high\u2010frequency sensorineural hearing loss: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5986-2148","authenticated-orcid":false,"given":"K.\u2010H.","family":"Lien","sequence":"first","affiliation":[{"name":"Division of Otology, Department of Otolaryngology Head and Neck Surgery Chang Gung Memorial Hospital, Linkou Taoyuan Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences, College of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-4500","authenticated-orcid":false,"given":"T.\u2010Y.","family":"Ger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chang Gung Memorial Hospital, Linkou Taoyuan Taiwan"},{"name":"Graduate Institute of Biomedical Engineering College of Engineering Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5699-0283","authenticated-orcid":false,"given":"C.\u2010C.","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chang Gung Memorial Hospital, Linkou Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74298-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ds.ds_48_20"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163806"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0394-1"},{"key":"e_1_2_6_6_1","first-page":"e21","article-title":"Audiological abnormality and vitiligo","volume":"30","author":"Iannella G","year":"2017","journal-title":"Pigment Cell Melanoma Res"},{"key":"e_1_2_6_7_1","volume-title":"The Pigmentary System: Physiology and Pathophysiology","author":"Nordlund JJ","year":"2008"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)80327-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000697"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.00017.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/21695717.2018.1461488"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00463562"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-1300-7_5"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S201012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03605.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.84059"},{"key":"e_1_2_6_17_1","first-page":"n71","article-title":"PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJMJ","year":"2020","journal-title":"BMJ"},{"key":"e_1_2_6_18_1","unstructured":"PetersonJ WelchV LososMet\u2009al. 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