{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:10:07Z","timestamp":1792098607752,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006286","name":"Kongelig Hofbuntmager Aage Bangs Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ocular surface diseases (OSDs), including conjunctivitis and blepharitis, are common in atopic dermatitis (AD) patients, but the magnitude and patient characteristics are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the prevalence of OSDs in adults with AD and identify patient characteristics and risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We designed a cross\u2010sectional questionnaire\u2010based survey and sent it via a secure public mail to all adult Danes with a hospital diagnosis of AD (ICD\u201010 code L20.x) registered in the National Patient Register (<jats:italic>n<\/jats:italic>\u2009=\u200916\u2009718) between 2000 and 2019 and 7044 (42%) participated. Primary outcomes were OSDs and severity according to Ocular Surface Disease Index (OSDI). Adjusted odds ratios (aOR) were calculated with 95% confidence intervals (CIs) using logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Respondents were mostly females and middle\u2010aged (67.4%, mean [SD] age, 39.0 [15.5] years). Based on Patient\u2010Oriented SCORing Atopic Dermatitis 49% had mild AD, 35% moderate, 10% severe and in 6% AD was inactive; 44.3% reported physician\u2010diagnosed asthma bronchiale and 55.8% rhinitis. The lifetime prevalence of OSDs was 66.6% for conjunctivitis, 63.5% for hordeolum, 11.0% for blepharitis, 9.7% for keratitis, 2.0% for pterygium, 1.5% for symblepharon, 1.1% for keratoconus and 12.7% reported current conjunctivitis. Factors associated with lifetime occurrence of conjunctivitis included mild, moderate, and severe AD (aOR\u2009=\u20091.48 [95% CI, 1.02\u20132.14], aOR\u2009=\u20091.73 [95% CI, 1.19\u20132.53], aOR\u2009=\u20092.17 [95% CI, 1.42\u20133.21]), asthma bronchiale and rhinitis (aOR\u2009=\u20091.76 [95% CI, 1.49\u20132.07]), childhood\u2010onset of AD (aOR\u2009=\u20091.34 [95% CI, 1.16\u20131.56]) and systemic AD treatment (aOR\u2009=\u20091.27 [95% CI, 1.08\u20131.50]). Use of soft and hard contact lenses (aOR\u2009=\u20092.15 [95% CI, 1.65\u20132.80], aOR\u2009=\u20093.35 [95% CI, 1.62\u20136.92]) were associated with lifetime occurrence of keratitis. Moderate and severe AD, asthma bronchiale and rhinitis were also associated with a higher OSDI level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study identified important patient factors associated with OSDs. Clinicians should be attentive of ocular signs and symptoms in AD patients and ask about these.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17832","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T13:00:37Z","timestamp":1637672437000},"page":"592-601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Factors associated with ocular surface disease and severity in adults with atopic dermatitis: a nationwide survey"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9949-9726","authenticated-orcid":false,"given":"A.T.M.","family":"R\u00f8nnstad","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2010 Herlev and Gentofte Copenhagen Denmark"},{"name":"Copenhagen Research Group for Inflammatory Skin (CORGIS) Hellerup Denmark"},{"name":"Department of Dermatology Bispebjerg Hospital 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