{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:11:41Z","timestamp":1791346301988,"version":"4.3.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Benzyl alcohol is a widely used preservative, solvent and fragrance material. According to published data, it is a rare sensitizer in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify characteristics and sensitization patterns of patients with positive patch test reactions to benzyl alcohol and to check the reliability of the patch test preparation benzyl alcohol 1% pet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2010\u20132019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 70\u2009867 patients patch tested with benzyl alcohol 1% pet., 146 (0.21%) showed a positive reaction, most of them (89%) only weakly positive. The number of doubtful and irritant reactions significantly exceeded the number of positive reactions. Reproducibility of positive test reactions was low. Among benzyl alcohol\u2010positive patients, compared to benzyl alcohol\u2010negative patients, there were significantly more patients with leg dermatitis (17.8% vs. 8.6%), more patients aged 40\u2009years or more (81.5% vs. 70.5%) and more patients who were tested because of a suspected intolerance reaction to topical medications (34.9% vs. 16.6%). Concomitant positive reactions were mainly seen to fragrances, preservatives and ointment bases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sensitization to benzyl alcohol occurs very rarely, mainly in patients with stasis dermatitis. In view of our results, benzyl alcohol cannot be regarded as a significant contact allergen, and therefore marking it as skin sensitizer 1B and labelling it with H 317 is not helpful.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.17968","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T11:23:55Z","timestamp":1643196235000},"page":"866-872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Is benzyl alcohol a significant contact sensitizer?"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5047-8948","authenticated-orcid":false,"given":"J.","family":"Geier","sequence":"first","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) Institute at the University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4136-5036","authenticated-orcid":false,"given":"B.","family":"Ballmer\u2010Weber","sequence":"additional","affiliation":[{"name":"Clinic of Dermatology and Allergology Cantonal Hospital St. Gallen  St. Gallen Switzerland"},{"name":"Department of Dermatology, Venereology and Allergy University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3139-129X","authenticated-orcid":false,"given":"T.","family":"Buhl","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zuerich  Zuerich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rieker\u2010Schwienbacher","sequence":"additional","affiliation":[{"name":"Center for Dermatology, Phlebology and Allergology Klinikum Stuttgart  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6471-1811","authenticated-orcid":false,"given":"V.","family":"Mahler","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6837-4402","authenticated-orcid":false,"given":"H.","family":"Dickel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology St. Josef Hospital Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-2518","authenticated-orcid":false,"given":"S.","family":"Schubert","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) Institute at the University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the IVDK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Federal Institute for Occupational Safety and Health (BAuA).CLH report. 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