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Dupilumab is the first human monoclonal antibody approved for the treatment of AD. Its action is through IL\u20104 receptor alpha subunit inhibition, thus blocking IL\u20104 and IL\u201013 signaling pathways. It has been shown to be an effective, well\u2010tolerated therapy for AD, as well as for asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and eosinophilic esophagitis (EoE). However, an increasing incidence of dupilumab\u2010induced ocular surface disease (DIOSD) has been reported in patients treated with dupilumab, as compared to placebo. The aim of this study was to summarize scientific data regarding DIOSD in AD patients treated with dupilumab. A search of PubMed and clinicaltrials.gov databases was performed. There was no limit to study design. All AD cases were moderate\u2010to\u2010severe. DIOSD was either dermatologist\u2010, allergist\u2010, or ophthalmologist\u2010assessed. Evidence shows that DIOSD occurs most frequently in patients with atopic dermatitis and not in other skin conditions, neither in patients with asthma, CRSwNP, nor EoE who are on dupilumab treatment. Further studies are warranted in order to establish a causal relationship between dupilumab and ocular surface disease. Nevertheless, ophthalmological evaluations prior to dupilumab initiation can benefit AD patients with previous ocular pathology or current ocular symptomatology. Also, patch testing for ocular allergic contact dermatitis might be advantageous in patients with a history of allergic conjunctivitis. Furthermore, TARC, IgE, and circulating eosinophils levels might be important biomarkers for a baseline assessment of future candidates to dupilumab treatment. However, TARC measurements should be resumed for research purposes only.<\/jats:p>","DOI":"10.1111\/jdv.17981","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T20:59:11Z","timestamp":1644008351000},"page":"820-835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Dupilumab ocular side effects in patients with atopic dermatitis: a systematic review"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5452-7324","authenticated-orcid":false,"given":"N.","family":"Neagu","sequence":"first","affiliation":[{"name":"State Clinic of Dermatology Mure\u015f County Hospital  T\u00eergu Mure\u015f Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dianzani","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Unit Campus Bio\u2010Medico University of Rome  Rome 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