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We aimed to systematically review previously reported phenotypes of atopic dermatitis and any characteristics associated with them. Ovid EMBASE, Ovid MEDLINE and Web of Science were searched from inception till 12 February 2021 for studies attempting to classify atopic dermatitis. Primary outcomes are atopic dermatitis phenotypes and characteristics associated with them in subsequent analyses. A secondary outcome is the methodological approach used to derive them. In total, 8511 records were found. By focussing only on certain clinical phenotypes, 186 studies were eligible for inclusion. The majority of studies were hospital\u2010based (59%, 109\/186) and cross\u2010sectional (76%, 141\/186). The number of included patients ranged from seven to 526\u2009808. Data\u2010driven approaches to identify phenotypes were only used in a minority of studies (7%, 13\/186). Ninety\u2010one studies (49%) investigated a phenotype based on disease severity. A phenotype based on disease trajectory, morphology and eczema herpeticum was investigated in 56 (30%), 22 (12%) and 11 (6%) studies respectively. Thirty\u2010six studies (19%) investigated morphological characteristics in other phenotypes. Investigated associated characteristics differed between studies. In conclusion, we present an overview of phenotype definitions used in literature for severity, trajectory, morphology and eczema herpeticum, including associated characteristics. There is a lack of uniform and consistent use of atopic dermatitis phenotypes across studies.<\/jats:p>","DOI":"10.1111\/jdv.18008","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T10:23:13Z","timestamp":1645006993000},"page":"807-819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6807-6042","authenticated-orcid":false,"given":"A.L.","family":"Bosma","sequence":"first","affiliation":[{"name":"Department of Dermatology Amsterdam Public Health, Infection and Immunity Amsterdam UMC, location Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ascott","sequence":"additional","affiliation":[{"name":"Department of Dermatology Worthing University Hospitals Sussex NHS Foundation Trust Worthing UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Iskandar","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Farquhar","sequence":"additional","affiliation":[{"name":"NHS Greater Glasgow and Clyde Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Matthewman","sequence":"additional","affiliation":[{"name":"Department of Non\u2010communicable Disease Epidemiology London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.W.","family":"Langendam","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science Amsterdam Public Health Research Institute Amsterdam UMC, location Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mulick","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Abuabara","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.C.","family":"Williams","sequence":"additional","affiliation":[{"name":"Centre of Evidence\u2010Based Dermatology University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.I.","family":"Spuls","sequence":"additional","affiliation":[{"name":"Department of Dermatology Amsterdam Public Health, Infection and Immunity Amsterdam UMC, location Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Langan","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Middelkamp\u2010Hup","sequence":"additional","affiliation":[{"name":"Department of Dermatology Amsterdam Public Health, Infection and Immunity Amsterdam UMC, location Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31286-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12049"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-023097"},{"key":"e_1_2_8_5_1","unstructured":"PROSPERO protocol. 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