{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:11:51Z","timestamp":1790136711673,"version":"4.0.1"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Ultraviolet radiation is the main cause of skin pigmentation, but more recently visible light has been shown to be an important contributor especially in melano\u2010competent subjects. Photoprotection from visible light can improve several hyperpigmentation disorders. Recently, a visible light photoprotection assessment method has been proposed based on in\u2009vivo<\/jats:italic> pigmentation; the visible light photoprotection factor (VL\u2010PF) is determined by assessment of the change in colorimetry parameter ITA over several days measured using a chromameter. Although in\u2009vivo<\/jats:italic> methods remain the most representative of real life, in\u2009vitro<\/jats:italic> methods are more suited to screening sunscreen formulations.<\/jats:p><\/jats:sec>Objective<\/jats:title>The aim of this study was to evaluate the correlation between in\u2009vivo<\/jats:italic> and in\u2009vitro<\/jats:italic> methods in assessing protection against visible light induced pigmentation.<\/jats:p><\/jats:sec>Methods<\/jats:title>We first analysed the in\u2009vitro<\/jats:italic> protective properties of the 10 commercially available sunscreens using transmission measurements in the visible spectrum. Then, we performed a monocentric, double\u2010blind, randomized controlled study with intra\u2010individual comparisons in 20 healthy subjects and measure the VL\u2010PF in\u2009vivo<\/jats:italic> of those sunscreens. The correlation between the VL\u2010PF and the percentage of blocked light was evaluated using the coefficient of determination R<\/jats:italic>2<\/jats:sup>.<\/jats:p><\/jats:sec>Results<\/jats:title>A strong significant correlation was demonstrated between in\u2009vivo<\/jats:italic> visible light protection factor and in\u2009vitro<\/jats:italic> transmittance measurements, with the highest correlation factor at 420\u2009nm and in the spectrum covering from 400 to 469\u2009nm.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Transmittance measurements were found to be a good predictive tool to evaluate sunscreen visible light photoprotection efficacy and could be used to select formulations for final in\u2009vivo<\/jats:italic> testing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18034","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T08:24:49Z","timestamp":1646036689000},"page":"922-926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A new in\u2009vitro<\/i> method to predict in\u2009vivo<\/i> photoprotection of skin hyperpigmentation induced by visible light"],"prefix":"10.1111","volume":"36","author":[{"given":"L.","family":"Duteil","sequence":"first","affiliation":[{"name":"Center of Clinical Pharmacology Applied to Dermatology (CPCAD) L\u2019Archet 2 Hospital Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Cadars","sequence":"additional","affiliation":[{"name":"Research and Development Department NAOS Lyon 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