{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:22:04Z","timestamp":1778152924553,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Microscopic residual disease (MRD) after surgery can be a challenging situation in cutaneous squamous cell carcinoma (CSCC) and there is a lack of evidence concerning its management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the prognosis of CSCC with MRD and the usefulness of postoperative radiotherapy (PORT) in CSCC with MRD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study of CSCC with MRD through a 10\u2010year period (2010\u20132019) (<jats:italic>n<\/jats:italic>\u2009=\u2009244). Disease\u2010free survival and event\u2010free survival were assessed using R (v.3.4.1), considering competing risks. Evaluated outcomes were local recurrence (LR), nodal metastases (NMs), and disease\u2010specific death (DSD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 88y (IQR: 10.5). A total of 145 (59.43%) were men and 69 (28.28%) were immunosuppressed. Median tumour diameter and thickness were 19 and 6.4\u2009mm (IQR 11 and 5.5\u2009mm). Patients treated by re\u2010excision had a relapse rate of 4.3% compared with 11.30% and 29.71% in those who received PORT and observation (<jats:italic>P<\/jats:italic>\u2009=\u20090.045). The use of PORT was associated with a lower risk of LR compared with observation (HR\u2009=\u20090.206 [0.049\u20130.859], <jats:italic>P<\/jats:italic>\u2009=\u20090.030), but not with a lower risk of NMs or DSDs. In the multivariable models, PORT was again associated with a lower risk of LR than observation (HR\u2009=\u20090.167 [0.039\u20130.708], <jats:italic>P<\/jats:italic>\u2009=\u20090.014), but not with lower risk of metastasis and death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We always should try to obtain clear margins after surgery. PORT improves local control in CSCC with MRD, but when administered to the tumour bed, it does not reduce the risk of NM and DSD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18036","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T08:33:03Z","timestamp":1646037183000},"page":"846-854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcome of cutaneous squamous cell carcinoma with microscopic residual disease after surgery and usefulness of postoperative radiotherapy: a retrospective cohort study"],"prefix":"10.1111","volume":"36","author":[{"given":"L.","family":"Revelles\u2010Pe\u00f1as","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital of Salamanca  Salamanca 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