{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:49:39Z","timestamp":1787496579620,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T00:00:00Z","timestamp":1647648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitiligo is an acquired depigmentation disease of the skin due to melanocyte destruction. A shared pathogenesis affecting melanocytes in the cochlea has been postulated. However, the association between vitiligo and sensorineural hearing loss (SNHL) is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify the association between vitiligo and SNHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, nationwide cohort study included patients with vitiligo and age\u2010, sex\u2010 and comorbidities\u2010matched controls (propensity score matching; 1:4 ratio) from the National Health Insurance Research Database in Taiwan from 1 January 2000 to 31 December 2013.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 13\u2009048 patients with vitiligo and 52\u2009192 controls were included. SNHL developed in 0.61% patients with vitiligo and 0.29% controls. After adjusting for sex, age and comorbidities, a significant association between vitiligo and SNHL was found (adjusted hazard ratio, 2.18; 95% CI, 1.66\u20132.86). The other risk factors for developing SNHL included increased age, male sex, hyperlipidaemia, coronary artery disease and diffuse connective tissue diseases. In subgroup analysis, the association between vitiligo and SNHL remained significant in almost all the subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A 2.2\u2010fold increased risk of developing SNHL was found in patients with vitiligo. Proper referral to otologists for early screening and closer follow\u2010up of SNHL should be considered for patients with vitiligo, especially for patients with older age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.18047","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T03:36:37Z","timestamp":1646969797000},"page":"1097-1103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association between sensorineural hearing loss and vitiligo: a nationwide population\u2010based cohort study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0243-7858","authenticated-orcid":false,"given":"C.\u2010L.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Faculty of Medicine School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1160-5083","authenticated-orcid":false,"given":"S.\u2010H.","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Faculty of Medicine School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Institute of Biomedical Informatics National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Institute of Clinical Medicine School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Institute of Public Health and Department of Public Health National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Division of Translational Research and Center of Excellence for Cancer Research Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.\u2010H.","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Informatics National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010T.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Faculty of Medicine School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of Dermatology National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-3900","authenticated-orcid":false,"given":"C.\u2010Yi.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Faculty of Medicine School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Institute of Public Health and Department of Public Health National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of Dermatology National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60763-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12870"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.32710"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.05.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1616601"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0307-7772.2003.00738.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000226286.19295.34"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.107.3.453"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680070142026"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/010503998420568"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.11.007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350337"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.84059"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70196-0"},{"key":"e_1_2_7_16_1","first-page":"162","article-title":"Hypoacusis in vitiligo","volume":"70","author":"Sharma L","year":"2004","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03605.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2454-5929.ijohns20160958"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.12.029"},{"key":"e_1_2_7_20_1","volume-title":"National Health Insurance Annual Statistical Report 2019","author":"National Health Insurance Administration MoHaW, Taiwan, R.O.C","year":"2020"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.32"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.03952.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.10.010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01181.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14055"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1999.tb00518.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2008.12.005"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(86)90177-2"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000564"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38836"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.2430"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.01948.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2018.03.022"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckr176"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.5111870"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2012.04.012"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5453.658"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000134449.05454.82"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118850"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815575713"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2016.0153"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1993.01880140038006"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20130"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21039"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081314"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2011.588400"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060516688600"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18047","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.18047","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T13:08:25Z","timestamp":1692536905000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.18047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,19]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/jdv.18047"],"URL":"https:\/\/doi.org\/10.1111\/jdv.18047","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,19]]},"assertion":[{"value":"2021-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}