{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T21:30:41Z","timestamp":1777152641515,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["108\u20102314\u2010B\u2010075\u2010041\u2010MY3"],"award-info":[{"award-number":["108\u20102314\u2010B\u2010075\u2010041\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V110C\u2010021"],"award-info":[{"award-number":["V110C\u2010021"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Certain anti\u2010diabetic agents have been linked to the development of bullous pemphigoid (BP). However, the relationship between BP and sodium\u2010glucose co\u2010transporter 2 inhibitors (SGLT2is) remains inconclusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between SGLT2i usage and BP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were recruited from the Taiwan National Health Insurance Database between 2007 and 2018. A total of 149\u2009060 patients with diabetes receiving SGLT2i were matched 1\u2009:\u20092 with diabetic patients without SGLT2i usage. Factors such as age, sex, duration of diabetes condition, DPP4i usage, insulin usage and selected comorbidities were included in the multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the control, the 2\u2010year\u2010cumulative incidence was significantly low in patients using SGLT2i after adjustment for competing mortality. Patients with diabetes receiving SGLT2i had a low risk [adjusted hazard ratio (HR) 0.56, 95% confidence interval (CI), 0.33\u20130.96] for BP after adjustment for potential confounders. Age (HR, 1.06), renal disease (HR, 1.79), cerebrovascular disease (HR, 3.23), epilepsy (HR, 3.07), DPP4i users (HR: 2.55) and insulin users (HR: 2.56) were significant risk factors for BP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk of BP did not increase in patients receiving SGLT2i. Thus, SGLT2i could be a safe choice for patients with diabetes having additional risk factors or a history of BP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18106","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T19:13:43Z","timestamp":1648494823000},"page":"1318-1324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between sodium\u2010glucose co\u2010transporter 2 inhibitors and risk of bullous pemphigoid in patients with\u2009type 2 diabetes: a nationwide population\u2010based cohort\u2009study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1160-5083","authenticated-orcid":false,"given":"S.H.","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Faculty of Medicine School of Medicine National Yang Ming Chiao Tung University  Taipei 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