{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:36:51Z","timestamp":1790786211305,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003357"],"award-info":[{"award-number":["82003357"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972939"],"award-info":[{"award-number":["81972939"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003349"],"award-info":[{"award-number":["82003349"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073446"],"award-info":[{"award-number":["82073446"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dupilumab, an antibody against interleukin\u20104 receptor \u03b1, has demonstrated elegant efficacy and safety profiles in patients with moderate\u2010to\u2010severe atopic dermatitis (AD). However, the efficacy of dupilumab varies among AD patients, and compared with the Caucasian population, the data of dupilumab for Asian people, especially Chinese AD patients, is very limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the efficacy and safety of dupilumab for AD in a real\u2010world Chinese single\u2010centre prospective cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 138 moderate\u2010to\u2010severe AD patients receiving dupilumab treatment at Huashan Hospital, Shanghai, China in this 16\u2010week, single\u2010centre, prospective, open\u2010label study. The patients were evaluated at baseline, 2, 4, 8 and 16\u2009weeks after first dupilumab administration for multiple physician\u2010 and patient\u2010reported outcome measures. Blood eosinophil counts and total serum IgE were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were early and sustained improvement in all the efficacy measures evaluated after dupilumab administration. 64.5% AD patients achieved an improvement of \u226575% in the Eczema Area and Severity Index from baseline, and 60.9% patients achieved the Investigator's Global Assessment 0\/1 (or a reduction of \u22652 points from baseline) at week 16. The trunk demonstrated the most significantly decreased efficacy score [median decreased 96.24% (interquartile range, 89.04 to 100%)] compared with other body sites. Female (adjusted OR: 2.12, 95% confidence interval: 0.79\u20135.74) and body mass index (BMI) &lt;24 (3.03; 1.19\u20137.68) were identified as potential predictive factors of good response; while age &gt;60 (0.57; 0.10\u20133.28) predicted poor response. Adverse events were reported by 34.1% patients, and facial erythema (13%) and ocular symptoms (10.9%) were the most common.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dupilumab demonstrated favourable efficacy and well\u2010tolerated safety in Chinese AD patients in real\u2010world practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.18109","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T15:19:52Z","timestamp":1648480792000},"page":"1064-1073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Real\u2010world efficacy and safety of dupilumab in Chinese patients with atopic dermatitis: a single\u2010centre, prospective, open\u2010label study"],"prefix":"10.1111","volume":"36","author":[{"given":"C.","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Dermatology Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4119-2921","authenticated-orcid":false,"given":"Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College  Nanjing 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