{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:12:47Z","timestamp":1793923967762,"version":"4.8.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Moderate\u2010to\u2010severe atopic dermatitis (AD) in the adolescence is a high burden disease, and its treatment can be very challenging due to paucity of approved systemic drugs for this age and their side\u2010effects. Dupilumab was recently approved for treatment of adolescent AD.<\/jats:p><\/jats:sec>Objectives<\/jats:title>A multicentre, prospective, real\u2010world study on the effectiveness and safety of dupilumab in adolescents (aged from \u226512 to <18\u2009years) with moderate\u2010to\u2010severe AD was conducted. The main AD clinical phenotypes were also examined.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data of adolescents with moderate\u2010to\u2010severe AD treated with dupilumab at label dosage for 16\u2009weeks were collected. Treatment outcome was assessed by EASI, NRS itch, NRS sleep loss and CDLQI scores at baseline and after 16\u2009weeks of treatment. The clinical scores were also evaluated according to clinical phenotypes.<\/jats:p><\/jats:sec>Results<\/jats:title>One hundred and thirty\u2010nine adolescents were enrolled in the study. Flexural eczema and head and neck eczema were the most frequent clinical phenotypes, followed by hand eczema and portrait\u2010like dermatitis. Coexistence of more than 1 phenotype was documented in 126\/139 (88.5%) adolescents. Three patients (2.1%) contracted asymptomatic SARS\u2010CoV\u20102 infection and 1 of the discontinued dupilumab treatment before the target treatment period. A significant improvement in EASI, NRS itch, NRS sleep loss and CDLQI was observed after 16\u2009weeks of treatment with dupilumab. This outcome was better than that observed in clinical trials. Dupilumab resulted effective in all AD phenotypes, especially in diffuse eczema. Twenty\u2010eight (20.1%) patients reported adverse events, conjunctivitis and flushing being the most frequent. None of patients discontinued dupilumab due to adverse event.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Dupilumab in adolescent AD showed excellent effectiveness at week 16 with consistent improvement of all clinical scores. Moreover, dupilumab showed a good safety profile also in this COVID\u201019 pandemic era.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18141","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T14:15:21Z","timestamp":1649772921000},"page":"1292-1299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Moderate\u2010to\u2010severe atopic dermatitis in adolescents treated with dupilumab: A multicentre Italian real\u2010world experience"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-8141","authenticated-orcid":false,"given":"L.","family":"Stingeni","sequence":"first","affiliation":[{"name":"Dermatology Section, Department of Medicine and Surgery University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Dermatology Section, Department 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