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Approximately 4.4% of adults and up to 18.6% of children\/adolescents have AD in Europe, with 20% of all cases accounting for moderate\u2010to\u2010severe forms. This form of the condition in adults results in annual societal costs across Europe of an estimated \u20ac30\u2009billion; \u20ac15.2\u2009billion related to missed workdays or reduced work productivity, \u20ac10.1\u2009billion related to direct medical costs and \u20ac4.7\u2009billion related to personal expenditure of patients\/families. AD can also substantially impact physical, emotional, and social quality\u2010of\u2010life. Several studies have shown the debilitating itch\u2010scratch cycle is the main cause of the multifaceted burden, as it causes substantial sleep deprivation and stigmatisation due to the physical appearance of the skin, and confidence issues. These factors lead to psychosocial issues and can cumulate over time and prohibit patients reaching their \u2018full life potential\u2019. Despite this, many patients with the condition are undertreated, resulting in uncontrolled symptoms and a further strain placed on patients, society, and the economy. The authors of this White Paper comprise the European Atopic Dermatitis Working Group, which is a network of international specialists with expertise in dermatology and healthcare policy decisions. Their programme of action is focused on harnessing their expertise to build consensus, advance research, share knowledge, and ultimately seek to improve AD care outcomes through achieving long\u2010term symptom control. This White Paper presents a systematic evaluation of the overall financial and humanistic burden of moderate\u2010to\u2010severe AD and the current challenges that exist with AD care. 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