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In the 1970s, the chronic non\u2010bacterial osteomyelitis and chronic recurrent multifocal osteomyelitis were initially observed in paediatric patients with approximately 70% girls. Acne fulminans accompanied by polyarthralgia have been observed since early 1970s, which almost exclusively occurs in adolescent boys. Report on spondyloarthropathy associated with hidradenitis suppurativa can be traced back to 1982. The SAPHO syndrome was coined in 1987 to lump together synovitis, acne, pustulosis, hyperostosis and osteitis to conceptualize a group of inflammatory osteocutaneous diseases of unclear etiopathogenesis and ill\u2010defined associations spanning disparate age and gender groups. From historical view, Sasaki syndrome is proposed to replace SAPHO syndrome to represent PPP with sternocostoclavicular arthropathy in the absence of other skin manifestations. Hidradenitis suppurativa is folliculitis in pathogenesis and no longer classified as acne. PPP accompanied by psoriasis vulgaris is more likely psoriasis pustulosa palmoplantaris in dermatological aspect, and the associated arthritis is part of psoriatic arthropathy. Pathophysiology of these disorders is incompletely understood. To echo the advancement of high\u2010throughput sequencing, splitting but not lumping of clinical findings would be a better strategy to decipher these multigenic complex inflammatory disorders.<\/jats:p>","DOI":"10.1111\/jdv.18172","type":"journal-article","created":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T08:32:50Z","timestamp":1650789170000},"page":"1501-1506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Does <scp>SAPHO<\/scp> syndrome exist in dermatology?"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7720-0228","authenticated-orcid":false,"given":"W.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9274-7050","authenticated-orcid":false,"given":"T.","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-6993","authenticated-orcid":false,"given":"S.\u2010H.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chang Gung Memorial Hospital Kaohsiung Medical Center  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3934-4938","authenticated-orcid":false,"given":"Z.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Southwest Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Al\u2010Khuzaei","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rumailah Hospital Hamad Medical Cooperation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-0466","authenticated-orcid":false,"given":"A.G.","family":"Jurik","sequence":"additional","affiliation":[{"name":"Department of Radiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-4330","authenticated-orcid":false,"given":"G.","family":"Plewig","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Ludwig\u2010Maximilian\u2010University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"187","article-title":"Acne\u2010pustulosis\u2010hyperostosis\u2010osteitis syndrome. 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