{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:30:17Z","timestamp":1787632217751,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hidradenitis suppurativa (HS) is a relatively common chronic inflammatory condition of intertriginous skin. In recent years, the neutrophil\/lymphocyte ratio (NLR), platelet\/lymphocyte ratio (PLR), monocyte\/lymphocyte ratio (MLR) and platelet\/neutrophil ratio (PLR) have been shown to be indicators of systemic inflammation correlating with severity of inflammatory conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to analyse for the first time the systemic inflammation biomarkers also including the pan\u2010immune\u2010inflammation value (PIV) and the systemic immune\u2010inflammation index (SII) in HS patients and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study retrospectively investigated clinical and laboratory data of 142 patients with HS. Moreover, a sex\u2010age\u2010matched healthy control group was included. The severity of HS was routinely assessed by the Hurley staging, the mHSS and the SAHS score. All inflammation\u2010based biomarkers were calculated from absolute values of complete blood counts. Receiver\u2010operating characteristics analyses, including the Youden index, were performed in order to determine optimal cut\u2010off values and test performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Whereas PIV and SII were significantly higher in HS patients, PLR, MLR and PNR were significantly lower in HS patients when compared to controls. Almost all inflammation\u2010based biomarkers significantly correlated with disease severity. However, PIV was the only test that was significantly associated with HS severity as indicated by a Youden index of 0.56 (associated criterion: 756.4; AUC: 0.79, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although all systemic inflammation\u2010based biomarkers investigated are more or less associated with HS severity, the PIV appears to have the best performance in this regard. It may be employed in adjunction with the clinical scores for treatment decision making or clinical trial assessments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18175","type":"journal-article","created":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T08:32:50Z","timestamp":1650789170000},"page":"1593-1596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Complete blood collection\u2010based systemic inflammation biomarkers for patients with hidradenitis suppurativa"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7862-3695","authenticated-orcid":false,"given":"T.","family":"Gambichler","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hessam","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Cramer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Abu Rached","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.G.","family":"Bechara","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.1677"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.5890"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15748"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.052"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2019.31.6.601"},{"key":"e_1_2_8_7_1","first-page":"368","article-title":"The relationship between neutrophil\/lymphocyte and platelet\/lymphocyte ratios with oxidative stress in active Crohn's disease patients","volume":"20","author":"Eraldemir FC","year":"2016","journal-title":"Hippokratia"},{"key":"e_1_2_8_8_1","first-page":"352","article-title":"Systemic immune\u2010inflammation index (SII) predicts increased severity in psoriasis and psoriatic arthritis","volume":"46","author":"Yorulmaz A","year":"2020","journal-title":"Curr Health Sci J"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-0894-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.900212"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14835"},{"key":"e_1_2_8_12_1","first-page":"87","article-title":"Evaluating the use of hematological parameters in staging hidradenitis suppurativa","volume":"28","author":"Ya\u015far NF","year":"2016","journal-title":"Wounds"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446021"}],"container-title":["Journal of the European Academy of Dermatology and 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