{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T03:38:51Z","timestamp":1774669131516,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chlormethine gel is a skin\u2010directed therapy used for patients with mycosis fungoides (MF) that showed a favourable risk\/benefit profile in a randomized clinical trial. Currently, data on chlormethine gel use in real\u2010world settings are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to assess safety and efficacy of chlormethine gel treatment in patients treated during daily clinical practice and investigate associations between response and disease stage, lesion type, mono\u2010 or combination therapy, and occurrence of dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data from patients using chlormethine gel from three sites in Greece were analysed. Efficacy was assessed through modified Severity\u2010Weighted Assessment Tool (mSWAT) scores. Safety assessments included analysis of the occurrence and severity of dermatitis. The Skindex\u201029 questionnaire was used for quality\u2010of\u2010life assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010eight patients were included. The overall response rate (ORR) increased from 37.9% at month 1 to 80.8% at month 9. For 64.2% of patients, response was maintained for at least 4\u2009months (ORR4). At month 3, a higher ORR was seen for patients with patches (69.7%) than patients with plaques\/tumours (both 15.2%). A higher ORR4 was observed for patients with early\u2010 vs late\u2010stage disease (71.4% vs. 36.4%) and patients on mono\u2010 vs combination therapy (75% vs. 47.6%). Dermatitis was observed in the majority of patients (72.4%), but the presence or severity of dermatitis was not directly correlated with treatment response. Both mSWAT and Skindex\u201029 scores decreased significantly during treatment, and changes in these scores from baseline to month 6 showed a positive correlation (<jats:italic>r<\/jats:italic>\u2009=\u20090.55, <jats:italic>P<\/jats:italic>\u2009=\u20090.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chlormethine gel was effective for the treatment of skin lesions in patients with early\u2010 and late\u2010stage MF in clinical practice. Response rates increased over time, indicating that continued treatment with the gel is important. Dermatitis may be managed by reducing the treatment frequency; the occurrence of dermatitis did not affect the response to treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18183","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T08:11:17Z","timestamp":1650960677000},"page":"1751-1757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Chlormethine gel is effective for the treatment of skin lesions in patients with early\u2010 and late\u2010stage mycosis fungoides in clinical practice"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8634-102X","authenticated-orcid":false,"given":"E.","family":"Papadavid","sequence":"first","affiliation":[{"name":"2nd Department of Dermatology and Venereology National and Kapodistrian University of Athens, \u201cAttikon\u201d University General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Koumourtzis","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology National and Kapodistrian University of Athens, \u201cAttikon\u201d University General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-9152","authenticated-orcid":false,"given":"V.","family":"Nikolaou","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology and Venereology National and Kapodistrian University of Athens, University of Athens Medical School, \u201cAndreas Sygros\u201d Hospital for Skin Diseases  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Lampadaki","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology National and Kapodistrian University of Athens, \u201cAttikon\u201d University General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Marinos","sequence":"additional","affiliation":[{"name":"Department of Hematopathology Evangelismos General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9616-2001","authenticated-orcid":false,"given":"A.","family":"Patsatsi","sequence":"additional","affiliation":[{"name":"2nd Dermatology Department Aristotle University, School of Medicine, Papageorgiou General Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Georgiou","sequence":"additional","affiliation":[{"name":"2nd Dermatology Department Aristotle University, School of Medicine, Papageorgiou General Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Dalamaga","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, School of Medicine National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Stratigos","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology and Venereology National and Kapodistrian University of Athens, University of Athens Medical School, \u201cAndreas Sygros\u201d Hospital for Skin Diseases  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.02.027"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/cco.2018.11.03"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy133"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2020.02.010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17240"},{"key":"e_1_2_7_7_1","unstructured":"National Comprehensive Cancer Network.NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae). 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