{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:04:54Z","timestamp":1778771094537,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atopic dermatitis (AD) is associated with an increased risk for viral infections including those caused by herpes simplex virus and varicella zoster virus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study examined treatment\u2010emergent (TE) herpes simplex infection including eczema herpeticum (EH), and herpes zoster (HZ), in adult patients with AD receiving \u22651 dose of baricitinib (BARI), an oral selective inhibitor of Janus kinase 1\/2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated data from six double\u2010blinded, randomized, placebo\u2010controlled (PC) trials and two long\u2010term extension studies, within three analysis sets: PC, 2\u20134\u2010mg BARI extended and All\u2010BARI\u2010AD. Frequency, incidence rate (IR)\/100 person\u2010years (PYs) and clinical characteristics of TE\u2010herpes simplex, EH and HZ were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the All\u2010BARI\u2010AD dataset (<jats:italic>n<\/jats:italic>\u2009=\u20092531; 2247 PYs), herpes simplex was reported in 8.9% of patients (<jats:italic>n<\/jats:italic>\u2009=\u2009224; IR\u2009=\u200910.3). Most herpes simplex events were rated as mild or moderate (93.3%), rarely led to permanent discontinuation (2.2%) and presented mostly as oral\/perioral herpes simplex (51.3%). TE\u2010EH occurred at a low frequency (All\u2010BARI\u2010AD 1.7% <jats:italic>n<\/jats:italic>\u2009=\u200943; IR\u2009=\u20092.0) and were reported in 0.5%, 0.2% and 1.4% of patients receiving placebo, 2\u2010mg or 4\u2010mg BARI respectively. In the All\u2010BARI\u2010AD dataset, most events were investigator\u2010rated as mild\/moderate (79.1%), affected \u22642% of the body surface area (74.2%) and occurred as single events (88.4%). Serious TE\u2010EH (<jats:italic>n<\/jats:italic>\u2009=\u200911) occurred exclusively in patients with poor disease control (vIGA\u2010AD\u2122 score\u2009\u22653) at infection onset. TE\u2010HZ was reported in 2.1% of BARI patients (<jats:italic>n<\/jats:italic>\u2009=\u200953; IR\u2009=\u20092.3), without a dose relationship during the PC period (IR\u2009=\u20092.7 and IR\u2009=\u20090.0) or the extended dataset (IR\u2009=\u20093.7 and IR\u2009=\u20091.7) for 2\u2010 or 4\u2010mg BARI respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TE\u2010herpes simplex was common, while occurrence of EH was uncommon. Most events of EH were localized with involvement of a small BSA and were linked to poor disease control. Events of HZ were rare in the PC dataset and without a dose dependent increase in frequency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18193","type":"journal-article","created":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T12:23:02Z","timestamp":1651407782000},"page":"1486-1496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["An integrated analysis of herpes virus infections from eight randomized clinical studies of baricitinib in adults with moderate\u2010to\u2010severe atopic dermatitis"],"prefix":"10.1111","volume":"36","author":[{"given":"T.","family":"Werfel","sequence":"first","affiliation":[{"name":"Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy Hannover Medical School  Hannover Germany"},{"name":"Cluster of Excellence RESIST (EXC 2155) Hannover Medical School  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.D.","family":"Irvine","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Trinity College  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bangert","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1139-0908","authenticated-orcid":false,"given":"J.","family":"Seneschal","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pediatric Dermatology and National Reference Center for Rare Skin Disorders H\u00f4pital Saint\u2010Andr\u00e9  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Grond","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana 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Ludwig Maximillian University  Munich Germany"},{"name":"Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel) Department of Dermatology  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.12.073"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-019-08768-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0383-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000526"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.010"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.06.047"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18898"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221276"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16948"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.008"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16090"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00896-X"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.020"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16892"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00445-7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.05.024"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.052"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40189"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20887"},{"key":"e_1_2_10_21_1","first-page":"452","article-title":"Plasmacytoid 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