{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:39:13Z","timestamp":1790897953504,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cutaneous adnexal tumours (ATs) encompass a variegated group of hamartomas and benign or malignant tumours, originating from the hair follicle, sebaceous, eccrine or apocrine glands that may simulate other cutaneous neoplasms. This study aims to provide a comprehensive overview of the spectrum of clinical and dermoscopic features of ATs, to better define these lesions and assist in the differential diagnosis. We performed a two\u2010step systematic search of the literature in PubMed, Embase and Cochrane Library databases from inception until 4 September 2020. In the first step, we aimed to define histological variants of ATs with descriptions of dermoscopic criteria. The second step included a search for the name of each previously identified AT variants in the same databases adding \u2018AND (epilum* or dermosc* or dermatosc*)\u2019. All study types in English language reporting dermoscopic images of ATs were included. Collisions between ATs and other inflammatory or neoplastic skin lesions were excluded, with the exception of collisions with a sebaceous nevus. The protocol of this study was prospectively registered in PROSPERO (CRD42021244677). In total, 206 articles met our inclusion criteria, encompassing 372 ATs in 365 patients. Most ATs were apocrine\u2010eccrine (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009217, 58.3%,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009173 benign) with a prevalence of poromas (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200982), followed by follicular ATs (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200988, 23.7%,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200983 benign) and sebaceous ATs (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200967, 18.0%,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200949 benign). Most patients had a single AT lesion (320, 86.0%), while 42 (11.3%) had multiple ATs. A syndrome causing multiple ATs was identified in 15 patients. Histopathological analysis revealed 82% benign (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009305) and 18.0% malignant (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200967). ATs were classified according to their ability to mimic four groups of more common skin tumours: basal cell carcinoma, squamous cell carcinoma, melanocytic lesions and benign cutaneous lesions. Moreover, we have highlighted the ability of malignant variants of ATs to simulate benign skin lesions. This systematic review offers a comprehensive overview of the common clinical and dermoscopic features of follicular, sebaceous and apocrine\u2010eccrine ATs and details possible differential dermoscopic features.\n                  <\/jats:p>","DOI":"10.1111\/jdv.18210","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T11:19:22Z","timestamp":1652181562000},"page":"1524-1540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2180-7984","authenticated-orcid":false,"given":"M.","family":"Lai","sequence":"first","affiliation":[{"name":"Centro Oncologico ad Alta Tecnologia Diagnostica Azienda Unit\u00e0 Sanitaria Locale \u2010 IRCCS di Reggio Emilia  Reggio Emilia Italy"},{"name":"Department of Dermatology University of Modena and Reggio Emilia  Modena Italy"},{"name":"Clinical and Experimental Medicine PhD Program University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Muscianese","sequence":"additional","affiliation":[{"name":"Private Practice  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4875-6977","authenticated-orcid":false,"given":"S.","family":"Piana","sequence":"additional","affiliation":[{"name":"Pathology Unit Azienda Unit\u00e0 Sanitaria Locale \u2010 IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2866-0783","authenticated-orcid":false,"given":"J.","family":"Chester","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Borsari","sequence":"additional","affiliation":[{"name":"Centro Oncologico ad Alta Tecnologia Diagnostica Azienda Unit\u00e0 Sanitaria Locale \u2010 IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Paolino","sequence":"additional","affiliation":[{"name":"Unit of Dermatology IRCCS San Raffaele Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-2951","authenticated-orcid":false,"given":"G.","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences La Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8218-3896","authenticated-orcid":false,"given":"C.","family":"Longo","sequence":"additional","affiliation":[{"name":"Centro Oncologico ad Alta Tecnologia Diagnostica Azienda Unit\u00e0 Sanitaria Locale \u2010 IRCCS di Reggio Emilia  Reggio Emilia Italy"},{"name":"Department of Dermatology University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7699-879X","authenticated-orcid":false,"given":"R.","family":"Pampena","sequence":"additional","affiliation":[{"name":"Centro Oncologico ad Alta Tecnologia Diagnostica Azienda Unit\u00e0 Sanitaria Locale \u2010 IRCCS di Reggio Emilia  Reggio Emilia Italy"},{"name":"Department of Dermatology University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"951","volume-title":"Weedon's Skin Pathology","author":"Patterson JW","year":"2020"},{"key":"e_1_2_8_3_1","volume-title":"WHO Classification of Skin Tumours","author":"Elder D","year":"2018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2018.05.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"e_1_2_8_7_1","unstructured":"National Institute for Health Research.Clinical and dermoscopic features of adnexal skin tumors: a systematic review of the literature. 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