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Recent advances on OLP pathogenesis suggest the presence of Th17 cells and the up\u2010regulation of interleukin\u201017 (IL\u201017) expression are crucial events. Our aim was to test the hypothesis in the literature about an important role of IL\u201017 in OLP by systematically investigating the overexpression of IL\u201017 in the lesional tissue and blood from OLP patients and healthy controls. A total of 22 studies comprising 658 OLP patients and 362 control subjects fulfilled inclusion criteria were subjected to meta\u2010analysis. The assessment of IL\u201017 in the lesional tissue by quantitative real\u2010time polymerase chain reaction (PCR) revealed a significant elevation in the OLP group (RR:1.35 95%CI: 0.20\u20132.50, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200992%). There was a statistical overexpression of IL\u201017 in the serum of OLP group detected by ELISA (RR:2.47 95%CI: 1.17\u20133.77, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200997%) and flow cytometry (RR:3.04 95%CI: 0.69\u20135.39, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200997%). In the erosive OLP group, the tissue IL\u201017 assessed by PCR was higher than in reticular OLP patients (RR:0.78 95%CI: 0.21\u20131.36, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%). Peripheral assessment of IL\u201017 by ELISA (RR:1.43 95%CI: 0.01\u20132.85, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200994%) and flow cytometry (RR:1.55 95%CI: 0.29\u20132.81, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200989%) revealed significant elevation in erosive OLP group. The dominating overexpression of IL\u201017 and Th17 cells in the local inflammatory inf\u00edltrate and serum of OLP patients confirms its role, probably in the interaction between T cells and keratinocytes. Notably, the upregulation of IL\u201017 is more intense in erosive than in reticular OLP suggesting a positive correlation between IL\u201017 levels and disease severity. Further research is warranted to investigate the potential role of anti\u2010IL\u201017 drugs to manage this chronic condition.<\/jats:p>","DOI":"10.1111\/jdv.18219","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T06:21:47Z","timestamp":1652682107000},"page":"1735-1744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Potential role of INTERLEUKIN\u201017 in the pathogenesis of oral lichen planus: a systematic review with META\u2010analysis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-0206","authenticated-orcid":false,"given":"H.","family":"Husein\u2010ElAhmed","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Hospital de Baza  Granada Spain"},{"name":"Translational Research Institute  Hamad Medical Corporation Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Steinhoff","sequence":"additional","affiliation":[{"name":"Translational Research Institute  Hamad Medical Corporation Doha Qatar"},{"name":"Department of Dermatology and Venereology  Hamad Medical Corporation Doha Qatar"},{"name":"Weill Cornell Medicine\u2010Qatar College of Medicine  Doha Qatar"},{"name":"Qatar University, Medical School  Doha Qatar"},{"name":"Department of Dermatology Weill Cornell Medicine  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2014.01.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01441.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01608.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.08.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.02.044"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2295"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1698"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03240.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01162"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2010.11.006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.03.031"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.12.007"},{"key":"e_1_2_9_15_1","first-page":"e123","article-title":"Tetzlaff jet\u2009al. 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