{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:13:49Z","timestamp":1792145629320,"version":"4.4.0"},"reference-count":76,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of the skin and mucous membranes. This disease typically affects the elderly and presents with itch and localized or, most frequently, generalized bullous lesions. A subset of patients only develops excoriations, prurigo\u2010like lesions, and eczematous and\/or urticarial erythematous lesions. The disease, which is significantly associated with neurological disorders, has high morbidity and severely impacts the quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives and methodology<\/jats:title>\n                    <jats:p>The Autoimmune blistering diseases Task Force of the European Academy of Dermatology and Venereology sought to update the guidelines for the management of BP based on new clinical information, and new evidence on diagnostic tools and interventions. The recommendations are either evidence\u2010based or rely on expert opinion. The degree of consent among all task force members was included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Treatment depends on the severity of BP and patients' comorbidities. High\u2010potency topical corticosteroids are recommended as the mainstay of treatment whenever possible. Oral prednisone at a dose of 0.5\u2009mg\/kg\/day is a recommended alternative. In case of contraindications or resistance to corticosteroids, immunosuppressive therapies, such as methotrexate, azathioprine, mycophenolate mofetil or mycophenolate acid, may be recommended. The use of doxycycline and dapsone is controversial. They may be recommended, in particular, in patients with contraindications to oral corticosteroids. B\u2010cell\u2010depleting therapy and intravenous immunoglobulins may be considered in treatment\u2010resistant cases. Omalizumab and dupilumab have recently shown promising results. The final version of the guideline was consented to by several patient organizations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The guidelines for the management of BP were updated. They summarize evidence\u2010 and expert\u2010based recommendations useful in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.18220","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T10:08:39Z","timestamp":1656497319000},"page":"1689-1704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":282,"title":["Updated\n                    <scp>S2<\/scp>\n                    K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology (\n                    <scp>EADV<\/scp>\n                    )"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0424-6297","authenticated-orcid":false,"given":"L.","family":"Borradori","sequence":"first","affiliation":[{"name":"Department of Dermatology Inselspital, Bern University Hospital Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3265-0011","authenticated-orcid":false,"given":"N.","family":"Van Beek","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0883-3210","authenticated-orcid":false,"given":"C.","family":"Feliciani","sequence":"additional","affiliation":[{"name":"Dermatology Unit Department of Medicine and Surgery University Hospital University of Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Tedbirt","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rouen University Hospital, Referral Center for Autoimmune Bullous Diseases Referral Center for Autoimmune Bullous Diseases Rouen University Hospital INSERM U1234, Normandie University Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-4433","authenticated-orcid":false,"given":"E.","family":"Antiga","sequence":"additional","affiliation":[{"name":"Section\u00a0of Dermatology Department of Health Sciences University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rambam Health Care Campus Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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