{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T14:09:05Z","timestamp":1772374145140,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The proportion of Merkel cell carcinomas (MCCs) in solid\u2010organ transplant recipients (SOTR) harbouring Merkel cell polyomavirus (MCPyV) is unknown, as are factors affecting their outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe clinicopathological features of MCC in SOTR, investigate the tumoral MCPyV\u2010status and identify factors associated with tumour outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective, international, cohort\u2010study. MCPyV\u2010status was investigated by immunohistochemistry and polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 30 SOTR and 44 consecutive immunocompetent patients with MCC were enrolled. SOTR were younger at diagnosis (69 vs<jats:italic>.<\/jats:italic> 78\u2009years, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Thirty\u2010three percent of SOTR MCCs were MCPyV\u2010positive vs<jats:italic>.<\/jats:italic> 91% of immunocompetent MCCs (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Solid\u2010organ transplantation was associated with an increased cumulative incidence of progression (SHR: 3.35 [1.57\u20137.14], <jats:italic>P<\/jats:italic>\u2009=\u20090.002), MCC\u2010specific mortality (SHR: 2.55 [1.07\u20136.06], <jats:italic>P<\/jats:italic>\u2009=\u20090.034) and overall mortality (HR: 3.26 [1.54\u20136.9], <jats:italic>P<\/jats:italic>\u2009=\u20090.002). MCPyV\u2010positivity and switching to an mTOR inhibitor (mTORi) after MCC diagnosis were associated with an increased incidence of progression (SHR: 4.3 [1.5\u201313], <jats:italic>P<\/jats:italic>\u2009=\u20090.008 and SHR: 3.6 [1.1\u201312], <jats:italic>P<\/jats:italic>\u2009=\u20090.032 respectively) in SOTR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Retrospective design and heterogeneity of SOTR cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MCPyV appears to play a less prominent role in the aetiopathogenesis of MCC in SOTR. SOTR have a worse prognosis than their immunocompetent counterparts and switching to an mTORi after the diagnosis of MCC does not improve progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18256","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T08:01:46Z","timestamp":1653379306000},"page":"1991-2001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinicopathological features, <scp>MCPyV<\/scp> status and outcomes of Merkel cell carcinoma in <scp>solid\u2010organ<\/scp> transplant recipients: a retrospective, multicentre cohort study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3688-9596","authenticated-orcid":false,"given":"C.","family":"Ferr\u00e1ndiz\u2010Pulido","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona  Barcelona 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