{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:53:45Z","timestamp":1793325225295,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pruritus is prevalent in psoriasis but still many features of pruritus, its response to therapy and its burden in psoriasis remain to be better characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate characteristics and burden of pruritus in an international cohort of patients with psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included a total of 634 patients and 246 controls from Germany, Poland and Russia. Physicians examined and interviewed participants, recording clinical characteristics, such as severity, therapy and localization of psoriatic lesions. Participants filled out self\u2010reported questionnaires including questions on pruritus severity and impact, characteristics, and response to therapy, and quality of life (QoL). Localization patterns of pruritus and skin lesions were visualized using body heat maps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most patients (82%) experienced pruritus throughout their disease, and 75% had current pruritus. The majority of patients (64%) perceived pure pruritus, and those who reported additional painful and\/or burning sensations (36%) reported overall stronger pruritus. The scalp was the most frequently reported localization of pruritus, even in the absence of skin lesions. Body surface area (BSA) of pruritus was not linked to pruritus intensity, but to BSA of psoriatic lesions (rho\u2009=\u20090.278;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). One third of patients (31%) reported impaired sex\u2010life, and 4% had suicidal ideations due to pruritus. In up to one third of patients, psoriasis therapies had little or no effect on pruritus. The only therapeutic option offered to some of these patients were antihistamines, which appeared to be effective in most cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pruritus is highly prevalent in psoriasis and is linked to a significant burden. Current psoriasis therapies are frequently insufficient to control pruritus. Managing psoriasis should include the assessment and control of itch. Efficient antipruritic therapies should be developed and be made available for patients with psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.18330","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T08:20:24Z","timestamp":1655194824000},"page":"2064-2075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A comprehensive, tri\u2010national, cross\u2010sectional analysis of characteristics and impact of pruritus in psoriasis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1537-2221","authenticated-orcid":false,"given":"M.","family":"Hawro","sequence":"first","affiliation":[{"name":"Department of Dermatology, Allergology and Venereology, Institute and Comprehensive Center for Inflammation Medicine University Medical Center Schleswig\u2010Holstein  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sahin","sequence":"additional","affiliation":[{"name":"Institute of Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Allergology and Immunology Fraunhofer Institute for Translational Medicine and Pharmacology ITMP  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ste\u0107","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Chair of Embedded Systems Architectures for Signal Processing University of Potsdam  Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"R\u00f3\u017cewicka\u2010Czaba\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Skin and Venereal Diseases Pomeranian Medical University  Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Raducha","sequence":"additional","affiliation":[{"name":"Department of Skin and Venereal Diseases Pomeranian Medical University  Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Garanyan","sequence":"additional","affiliation":[{"name":"V.A. Rakhmanov Department of Skin and Venereal Diseases I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Philipp","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Institute of Medical Immunology, Psoriasis Research and Treatment Center Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8042-7885","authenticated-orcid":false,"given":"G.","family":"Kokolakis","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Institute of Medical Immunology, Psoriasis Research and Treatment Center Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Christou","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Institute of Medical Immunology, Psoriasis Research and Treatment Center Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kolkhir","sequence":"additional","affiliation":[{"name":"Institute of Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Allergology and Immunology Fraunhofer Institute for Translational Medicine and Pharmacology ITMP  Berlin Germany"},{"name":"Division of Immune\u2010Mediated Skin Diseases I.M. 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