{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:02:50Z","timestamp":1791774170137,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012331","name":"LEO Fondet","doi-asserted-by":"publisher","award":["LF\u201018002"],"award-info":[{"award-number":["LF\u201018002"]}],"id":[{"id":"10.13039\/501100012331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NFF17OC0027594"],"award-info":[{"award-number":["NFF17OC0027594"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF14CC0001"],"award-info":[{"award-number":["NNF14CC0001"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Research on hyperhidrosis comorbidities has documented the co\u2010occurrence of diseases but has not provided information about temporal disease associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the temporal disease trajectories of individuals with hospital\u2010diagnosed hyperhidrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a hospital\u2010based nationwide cohort study including all patients with a hospital contact in Denmark between 1994 and 2018. International Classification of Diseases version\u201010 diagnoses assigned to inpatients, outpatients and emergency department patients were collected from the Danish National Patient Register. The main outcome was the temporal disease associations occurring in individuals with hyperhidrosis, which was assessed by identifying morbidities significantly associated with hyperhidrosis and then examining whether there was a significant order of these diagnoses using binomial tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 7\u2009191\u2009519 patients were included. Of these, 8758 (0.12%) patients had localized hyperhidrosis (5674 female sex [64.8%]; median age at first diagnosis 26.9 [interquartile range 21.3\u201336.1]) and 1102 (0.015%) generalized hyperhidrosis (606 female sex [59.9%]; median age at first diagnosis 40.9 [interquartile range 26.4\u201360.7]). The disease trajectories comprised pain complaints, stress, epilepsy, respiratory and psychiatric diseases. The most diagnosed morbidities for localized hyperhidrosis were abdominal pain (relative risk [RR]\u2009=\u2009121.75; 95% Confidence Interval [CI] 121.14\u2013122.35;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), soft tissue disorders (RR\u2009=\u2009151.19; 95% CI 149.58\u2013152.80;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and dorsalgia (RR\u2009=\u2009160.15; 95% CI 158.92\u2013161.38;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The most diagnosed morbidities for generalized hyperhidrosis were dorsalgia (RR\u2009=\u2009306.59; 95% CI 302.17\u2013311.02;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), angina pectoris (RR\u2009=\u2009411.69; 95% CI 402.23\u2013421.16;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and depression (RR\u2009=\u2009207.92; 95% CI 202.21\u2013213.62;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). All these morbidities were diagnosed before hyperhidrosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This paper ascertains which hospital\u2010diagnosed morbidities precede hospital\u2010diagnosed hyperhidrosis. As hyperhidrosis mainly is treated in the primary health care sector, the trajectories suggests that these morbidities may lead to a worse disease course of hyperhidrosis that necessitates treatment in hospitals. Treating these morbidities may improve the disease course of hyperhidrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.18351","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T05:09:22Z","timestamp":1655960962000},"page":"2504-2511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The temporal association of hyperhidrosis and its comorbidities \u2013 a nationwide hospital\u2010based cohort study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1991-2248","authenticated-orcid":false,"given":"M.A.S.","family":"Henning","sequence":"first","affiliation":[{"name":"Deptartment of Dermatology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Reguant","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Protein Research University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.F.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Protein Research University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0159-670X","authenticated-orcid":false,"given":"R.K.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Deptartment of Dermatology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.S.","family":"Ibler","sequence":"additional","affiliation":[{"name":"Deptartment of Dermatology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.B.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Zealand University Hospital  K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.B.E.","family":"Jemec","sequence":"additional","affiliation":[{"name":"Deptartment of Dermatology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Brunak","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Protein Research University of Copenhagen  Copenhagen 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