{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:44:24Z","timestamp":1778910264884,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ultrasound (US)\u2010guided fine\u2010needle aspiration cytology (US\u2010FNAC) has improved the diagnosis of many malignancies, infections and other diseases as it is safe, simple, quick and accurate. In mycetoma, it is assumed that this technique may have a better diagnostic yield than the conventional FNAC as it can accurately identify the optimal site for the aspiration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the diagnostic yield of conventional FNAC with US\u2010FNAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This descriptive cross\u2010sectional hospital\u2010based study included 80 patients with clinically suspected mycetoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 80 patients included, 35 proved to have actinomycetoma, and 37 had eumycetoma based on surgical biopsies, histopathological examination and the culture of grains. Eight patients appeared to have no mycetoma. For actinomycetoma diagnosis, the US\u2010guided FNAC improved sensitivity to 97% and negative predictive value (NPV) to 83% compared to the conventional FNAC, which had 63% sensitivity; and NPV of 28%. No improvement was found for specificity. For eumycetoma, the conventional FNAC had 86.5% sensitivity, 100% specificity, 100% PPV and 37.5% NPV. The US\u2010FNAC for the diagnosis of eumycetoma had 100% sensitivity and specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and relevance<\/jats:title><jats:p>The obtained results showed that US\u2010FNAC is better than the conventional FNAC with lower false\u2010negative results. It can accurately distinguish between the two types of mycetoma, allowing rapid initiation of proper treatment. The technique can be used in rural areas with low resources and for epidemiological surveys as a quick screening tool for patients suspected of mycetoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18363","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T07:53:23Z","timestamp":1656057203000},"page":"1845-1850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ultrasound\u2010guided fine\u2010needle aspiration cytology significantly improved mycetoma diagnosis"],"prefix":"10.1111","volume":"36","author":[{"given":"E.E.","family":"Siddig","sequence":"first","affiliation":[{"name":"The Mycetoma Research Center University of Khartoum  Khartoum Sudan"},{"name":"Department of Medical Microbiology and Infectious Diseases ErasmusMC, University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences University of Khartoum  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"El Had Bakhait","sequence":"additional","affiliation":[{"name":"The Mycetoma Research Center University of Khartoum  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"El nour Hussein Bahar","sequence":"additional","affiliation":[{"name":"The Mycetoma Research Center University of Khartoum  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Siddig Ahmed","sequence":"additional","affiliation":[{"name":"The Mycetoma Research Center University of Khartoum  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.M.","family":"Bakhiet","sequence":"additional","affiliation":[{"name":"The Mycetoma Research Center University of Khartoum  Khartoum Sudan"},{"name":"Department of Molecular Biology Institute of Endemic Diseases, University of Khartoum  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Motasim Ali","sequence":"additional","affiliation":[{"name":"The Mycetoma Research Center University of Khartoum  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Babekir Abdallah","sequence":"additional","affiliation":[{"name":"The Mycetoma Research Center University of Khartoum  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ahmed Hassan","sequence":"additional","affiliation":[{"name":"The Mycetoma Research Center University of Khartoum  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Verbon","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases ErasmusMC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-8783","authenticated-orcid":false,"given":"W.W.J.","family":"van de Sande","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases ErasmusMC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4922-7321","authenticated-orcid":false,"given":"A.H.","family":"Fahal","sequence":"additional","affiliation":[{"name":"The Mycetoma Research Center University of Khartoum  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800791107"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/traa162"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002550"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008397"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trab032"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed3030097"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2021.106205"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005638"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/traa176"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008897"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-018-0287-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.172206"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007056"},{"key":"e_1_2_6_15_1","unstructured":"Aide memoire for Diagnostic Imaging Services.Geneva: World Health Organization.2009. 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