{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:34:39Z","timestamp":1792794879768,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Severity\u2010associated factors in atopic dermatitis (AD) have focussed on early onset, concomitant atopic diseases, markers of Th2\u2010shifted inflammation and filaggrin mutations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate factors associated with severe AD in Finnish patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a single\u2010centre, cross\u2010sectional observational study with 502\u2009AD patients aged 4.79 to 79.90\u2009years (mean 32.08\u2009years). Disease severity was assessed with the Rajka\u2013Langeland severity score and EASI and associated clinical signs were evaluated. Data regarding onset, relatives, atopic and other comorbidities was gathered retrospectively. We investigated total serum IgE\u2010levels, a panel of filaggrin null mutations and functional variants of genes associated with skin barrier defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Factors more frequent in severe AD included early onset (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004, 95%CI 0.000\u20130.024), male sex (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002, 95%CI 0.000\u20130.11), history of smoking (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.012, 95%CI 0.000\u20130.024), concomitant asthma (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001, 95%CI 0.000\u20130.011), palmar hyperlinearity (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.013, 95%CI 0.014\u20130.059), hand dermatitis (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.020, 95%CI 0.000\u20130.029) and history of contact allergy (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.042, 95%CI 0.037\u20130.096). Body mass indices (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.000, 95%CI 0.000\u20130.011) and total serum IgE\u2010levels (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.000, 95%CI 0.000\u20130.011) were higher in severe AD. No differences were observed for allergic rhinitis, allergic conjunctivitis, food allergy, peanut allergy, prick positivity, keratosis pilaris, history of herpes simplex infections, filaggrin null mutations and other gene variants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Severity determinants in Finnish patients seem to be early\u2010onset, male sex, smoking, overweight, concomitant asthma, palmar hyperlinearity, hand dermatitis and high IgE\u2010levels. A sub\u2010typing of patients in relation to confirmed severity determinants may be useful for course prediction, prognosis and targeted AD management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.18378","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T05:28:50Z","timestamp":1656480530000},"page":"2130-2139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Factors associated with severity of atopic dermatitis \u2013 a Finnish cross\u2010sectional study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5471-5894","authenticated-orcid":false,"given":"A.","family":"Salava","sequence":"first","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Salo","sequence":"additional","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lepp\u00e4nen","sequence":"additional","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lauerma","sequence":"additional","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Remitz","sequence":"additional","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2021.4169"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.08.028"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2023911"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1882"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0001-z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.06.044"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31286-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1941"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-015-0064-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.10.005"},{"key":"e_1_2_8_12_1","first-page":"121","article-title":"Risk factors of severe atopic dermatitis in childhood: single\u2010center experience","volume":"56","author":"Akan A","year":"2014","journal-title":"Turk J Pediatr"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.3668"},{"key":"e_1_2_8_14_1","first-page":"uxab009","article-title":"Predictive biomarker modeling of pediatric atopic dermatitis severity based on longitudinal serum collection","volume":"30","author":"Engle SM","year":"2021","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2018.39.4158"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2021.4045"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.05.034"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17132"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15912"},{"key":"e_1_2_8_20_1","first-page":"adv00368","article-title":"Are infants and toddlers with moderate\u2010to\u2010severe atopic dermatitis undertreated? Experiences of a finnish tertiary care hospital","volume":"101","author":"Antti A","year":"2021","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_8_21_1","first-page":"13","article-title":"Grading of the severity of atopic dermatitis","volume":"144","author":"Rajka G","year":"1989","journal-title":"Acta Derm Venereol Suppl (Stockh)"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05696.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19159"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2578"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010240"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17929"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-01895-z"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13689"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.017"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19597"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.4061"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17007"},{"key":"e_1_2_8_33_1","first-page":"593","article-title":"Comorbidities and treatment patterns in adult patients with atopic dermatitis: results from a nationwide multicenter study","volume":"7","author":"Campanati A","year":"2021","journal-title":"Arch Dermatol Res"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.11.006"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40733-021-00082-0"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16734"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124610"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2020.41.200067"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.07.014"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2021.100611"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14025"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12021"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.11.014"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14853"},{"key":"e_1_2_8_45_1","first-page":"664","article-title":"Risk of herpesvirus, serious and opportunistic infections in atopic dermatitis: a population\u2010based cohort study","volume":"8","author":"Wan J","year":"2021","journal-title":"Br J Dermatol"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10331.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2126"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14557"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17088"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.05.016"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10061298"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17471"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.09.031"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010021\u201008880\u20103"},{"key":"e_1_2_8_55_1","first-page":"889","article-title":"Safety of tacrolimus 0.03% and 0.1% ointments in young children with atopic dermatitis: a 36\u2010month follow\u2010up study","volume":"19","author":"Salava A","year":"2021","journal-title":"Clin Exp Dermatol"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18378","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.18378","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T15:01:18Z","timestamp":1692543678000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.18378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/jdv.18378"],"URL":"https:\/\/doi.org\/10.1111\/jdv.18378","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,22]]},"assertion":[{"value":"2022-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}