{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:30:47Z","timestamp":1780990247464,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD026880"],"award-info":[{"award-number":["S10OD026880"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD018522"],"award-info":[{"award-number":["S10OD018522"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Analyses of the hereditary propensity to dermatophytosis have revealed several proven genetic relationships. They include CARD9 deficiency, HLA\u2010DR4 and HLA\u2010DR8 type and genes encoding interleukin\u201022, defensin 2 and 4, and genetic defects in dectin\u20101, which increased the prevalence of dermatophytosis in families and were involved in the inheritance of susceptibility in their members.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To further investigate the genetic basis of dermatophytosis, we performed a genome\u2010wide association study (GWAS) of the UK Biobank cohort. To identify cases of dermatophytosis, we used ICD10 code B35, which covers Tinea barbae, Tinea capitis, Tinea unguium, Tinea manuum, Tinea pedis, Tinea corporis, Tinea imbricata, Tinea cruris, other dermatophytoses and dermatophytosis, unspecified. Data processing was performed on Minerva, a Linux mainframe with Centos 7.6, at the Icahn School of Medicine at Mount Sinai. We used PLINK, a whole\u2010genome association analysis toolset, to analyse the UKB chromosome files and the UK Biobank Data Parser (ukbb parser), a python\u2010based package that allows easy interfacing with the large UK Biobank dataset. We used LocusZoom for the Manhattan and q\u2010q plots. Other statistical analyses were done with R and SPSS 25.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Genome\u2010wide association study (GWAS) and meta\u2010analysis association statistics highlighted one susceptibility locus, Tubulointerstitial Nephritis Antigen (TINAG), with genome\u2010wide significance for dermatophytosis. The top SNP was rs16885197, a missense variant within TINAG, position chr6:54308557, alleles A\u2009&gt;\u2009G, minor allele frequency (MAF) 0.014. Multivariate logistic regression indicated that the minor G allele increased odds ratio of dermatophytosis by 7.8. Carrying two G alleles raised dermatophytosis odds ratio by a factor of 14.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More research into genetic and other predisposing factors for dermatophytosis is critical because of the implications for prophylaxis and therapy. It might be possible to prevent infection and recurrence by identifying people who are vulnerable to chronic dermatophytosis. Identifying high\u2010risk families would enable their members to be educated about the dangers of fungal diseases. New therapeutic techniques to target\u2009altered hormonal and immune response pathways might be created. TINAG is a prospective target that should be investigated, based on the findings of this article.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18413","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T08:34:43Z","timestamp":1657182883000},"page":"2482-2487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genome\u2010wide association study of dermatophytosis in the <scp>UK<\/scp> Biobank cohort"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-094X","authenticated-orcid":false,"given":"S.","family":"Lehrer","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.H.","family":"Rheinstein","sequence":"additional","affiliation":[{"name":"Severn Health Solutions  Severna Park MA 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