{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:06:14Z","timestamp":1785434774587,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300243"],"award-info":[{"award-number":["81300243"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although many studies have indicated that Psoriasis (PsO) could contribute to the risk of lung cancer, no study has reported a clear causal association between them. Our aim was to explore the potential causal association between PsO and the lung cancer risk using Mendelian randomization (MR) design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To explore a causal association between the PsO and lung cancer, we used large\u2010scale genetic summary data from genome\u2010wide association study (GWAS), including PsO (<jats:italic>n<\/jats:italic>\u2009=\u2009337\u2009159) and lung cancer (<jats:italic>n<\/jats:italic>\u2009=\u2009361\u2009586), based on previous observational studies. Our main analyses were conducted by inverse\u2010variance weighted (IVW) method with random\u2010effects model, with a complementary with the other two analyses: weighted median method and MR\u2010Egger approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of IVW methods demonstrated that genetically predicted PsO was significantly associated with higher odds of lung cancer, with an odds ratio (OR) of 1.06 (95%CI, 1.01\u20131.12; <jats:italic>P\u2009=<\/jats:italic>\u20090.02). Weighted median method and MR\u2010Egger regression also demonstrated directionally similar results (All <jats:italic>P\u2009&lt;<\/jats:italic>\u20090.05). In addition, both funnel plots and MR\u2010Egger intercepts indicated no directional pleiotropic effects between PsO and lung cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study provided potential evidence between genetically predicted PsO and lung cancer, which suggested that enhanced screening for lung cancer allows early detection of lung cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18437","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T04:59:54Z","timestamp":1658120394000},"page":"2113-2119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Psoriasis may increase the risk of lung cancer: a two\u2010sample Mendelian randomization study"],"prefix":"10.1111","volume":"36","author":[{"given":"Q.","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Cardiology Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-4086","authenticated-orcid":false,"given":"H.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu  Chengdu Sichuan 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