{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:38:48Z","timestamp":1790401128956,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dupilumab is the first biotherapy available for the treatment of moderate\u2010to\u2010severe childhood atopic dermatitis (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the effectiveness and safety of dupilumab in daily practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients aged 6\u201311, who had received a first dose of dupilumab, were included in this multicentre retrospective cohort study. The primary endpoint was change in SCORAD after 3\u2009months of treatment. Secondary endpoints were change in IGA score at 3\u2009months, proportion of patients with SCORAD50 and SCORAD75, description of adverse events and proportion of children in our cohort who would be excluded from pivotal phase 3 clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty patients were included. After 3\u2009months of treatment, there was a significant decrease in SCORAD (mean: 21.8\u2009\u00b1\u200913.8 vs 53.9\u2009\u00b1\u200918.5;<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and IGA (1.3\u2009\u00b1\u20090.8 vs 3.5\u2009\u00b1\u20090.7;<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Conjunctivitis was observed in 11.3% (<jats:italic>n<\/jats:italic>\u2009=\u20099\/80); three patients experienced dupilumab facial redness (DFR); 17.5% (<jats:italic>n<\/jats:italic>\u2009=\u200914\/80) reported injection site reactions; 6.3% (<jats:italic>n<\/jats:italic>\u2009=\u20095\/80) discontinued treatment. 61.2% (<jats:italic>n<\/jats:italic>\u2009=\u200949\/80) children were ineligible in the phase 3 trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>There is no control group. Because it was a real life study based on information from patient medical records in a French multicentre cohort, we cannot rule out the presence of reporting bias generated by the use of patient reported characteristics and missing information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These real\u2010life data confirm the efficacy and safety of dupilumab in children with moderate to severe AD extended to dyshidrosis and atopic prurigo, but it also revealed a lower frequency of DFR and conjunctivitis. However, administration in injectable form may be a barrier in this age group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18450","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T05:28:25Z","timestamp":1658294905000},"page":"2423-2429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Effectiveness and safety of dupilumab in the treatment of atopic dermatitis in children (6\u201311\u2009years): data from a French multicentre retrospective cohort in daily practice"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4105-4027","authenticated-orcid":false,"given":"A.","family":"Lasek","sequence":"first","affiliation":[{"name":"Department of Dermatology H\u00f4pital Saint Vincent de Paul, GHICL Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bellon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centre Hospitalier Universitaire Necker\u2010Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mallet","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Cancerology, H\u00f4pital de la Timone Assistance\u2010publique\u2010H\u00f4pitaux de Marseille Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Puzenat","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centre Hospitalier Universitaire de Besan\u00e7on Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.C.","family":"Bursztejn","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pitaux de Brabois CHRU Nancy Vand\u0153uvre\u2010L\u00e8s\u2010Nancy 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