{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:40:18Z","timestamp":1792701618325,"version":"4.5.0"},"reference-count":78,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cutaneous melanoma may have an adjacent nevus remnant on histological examination in 30% of cases (nevus\u2010associated melanoma, NAM), while it may appear\n                    <jats:italic>de novo<\/jats:italic>\n                    , without a precursor lesion, in the remaining 70% of cases. Nevus\u2010associated melanoma and the concept of acquired melanocytic nevi serving as precursors of melanoma has long been considered as a controversial topic. This controversy is, in part, due to their overall low rate of transformation to melanoma and scarce data on the natural history of progression. Another matter of debate regarded the possibility that the reported differences in NAM vs.\n                    <jats:italic>de novo<\/jats:italic>\n                    melanoma were due to an underestimation of NAM in thicker lesions due to obliteration of the nevus component by the tumour. During the last few years, several evidence has accumulated in order to address these controversies. In this review, we present a comprehensive synthesis of the epidemiological, clinical, dermoscopic and genetic findings in NAM, including thin NAM, compared to\n                    <jats:italic>de novo<\/jats:italic>\n                    melanoma. Answering the questions on nevus\u2010associated melanoma may provide further insight into the classification of these tumours and disentangle their biology and route of development from that of\n                    <jats:italic>de novo<\/jats:italic>\n                    melanoma.\n                  <\/jats:p>","DOI":"10.1111\/jdv.18453","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T11:53:38Z","timestamp":1658318018000},"page":"1927-1936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["A review of nevus\u2010associated melanoma: What is the evidence?"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-3410","authenticated-orcid":false,"given":"C.","family":"Dessinioti","sequence":"first","affiliation":[{"name":"1st Department of Dermatology\u2010Venereology National and Kapodistrian University of Athens, Andreas Sygros Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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