{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:35:03Z","timestamp":1780464903664,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871000"],"award-info":[{"award-number":["81871000"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901294"],"award-info":[{"award-number":["81901294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidemiological studies have suggested psoriasis was associated with an increased risk of Parkinson's disease (PD). However, whether psoriasis has an effect on PD progression is not explored yet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the causal role of psoriasis in PD progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a two\u2010sample Mendelian randomization analysis using summary statistics from genome\u2010wide association study of psoriasis (<jats:italic>N<\/jats:italic>\u2009=\u200933\u2009394), age at onset (<jats:italic>N<\/jats:italic>\u2009=\u200928\u2009568) and progression (<jats:italic>N<\/jats:italic>\u2009=\u20094093) of PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One standard deviation increase in genetically determined psoriasis risk was significantly associated with faster progression to dementia (OR\u2009=\u20091.07, 95% CI: 0.1.03\u20131.1, <jats:italic>P<\/jats:italic>\u2009=\u20094.71E\u201004). Meanwhile, higher psoriasis risk was nominally associated with faster progression of PD measured by time to Hoehn and Yahr stage 3 (OR\u2009=\u20091.05, 95% CI: 1.02\u20131.08, <jats:italic>P<\/jats:italic>\u2009=\u20091.53E\u201003) and depression (OR\u2009=\u20091.06, 95% CI: 1.02\u20131.11, <jats:italic>P<\/jats:italic>\u2009=\u20091.77E\u201003) of PD. The results were robust under all sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggested psoriasis accelerated overall progression of PD, and increased risk of dementia and depression of PD. A deeper understanding of neuroinflammation and immune response is likely to elucidate the potential pathogenesis of PD progression and identify novel therapeutic targets.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18459","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T18:03:40Z","timestamp":1658599420000},"page":"2401-2405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Psoriasis and progression of Parkinson's disease: a Mendelian randomization study"],"prefix":"10.1111","volume":"36","author":[{"given":"C.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatrics West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatrics West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Neurology, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatrics West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0947-1151","authenticated-orcid":false,"given":"H.","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatrics West China Hospital, Sichuan University  Chengdu Sichuan 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