{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:24:27Z","timestamp":1790810667184,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005190","name":"Melanoma Research Alliance","doi-asserted-by":"publisher","award":["654544"],"award-info":[{"award-number":["654544"]}],"id":[{"id":"10.13039\/100005190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is little understanding regarding the long\u2010term natural history of melanocytic nevi among adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of the study was to describe the long\u2010term natural history of individual nevi located on the torso of high\u2010risk patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients attending Memorial Sloan Kettering Cancer Center (MSKCC) who underwent two total body photography (TBP) sessions 15+\u2009years apart were included (\u2018retrospective\u2019 group). To account for a potential selection bias, we also included consecutive patients who had TBP 15+\u2009years ago and consented to undergo follow\u2010up TBP (\u2018prospective\u2019 group). We compared baseline and follow\u2010up torso images on the TBPs and evaluated the number of total, new and disappearing nevi; number of seborrheic keratoses and actinic keratoses; each nevus' diameter at both time points; each nevus' colour change; the presence of clinical atypia; and when dermoscopy was available, the dermoscopic features at each time point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred six patients were included in the study. Although the average age of the patients was 40 at baseline TBP, most patients developed new nevi between imaging sessions (median 16.4\u2009years) with an average of 2.6 (SD\u2009=\u20094.8) nevi per participant. The average number of disappearing nevi was 0.3 (SD\u2009=\u20090.6). In addition, 62\/106 (58%) patients had an absolute increase, and 9\/106 (8%) patients had an absolute decrease in their total nevus count. Roughly half (49%: 1416\/2890) of the nevi that could be evaluated at both time points increased in diameter by at least 25%. Only 6% (159\/2890) of nevi shrunk in diameter by at least 25%. Patients with a history of melanoma had a higher rate of disappearing nevi, and their nevi were more likely to grow. Most nevi demonstrated no significant dermoscopic changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High\u2010risk patients acquire new nevi throughout life with very few nevi disappearing over time. Contrary to prior reports, most nevi in adults increase in diameter, while few nevi shrink.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.18470","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T16:37:33Z","timestamp":1658853453000},"page":"2379-2387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The long\u2010term evolution of melanocytic nevi among high\u2010risk adults"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3360-2780","authenticated-orcid":false,"given":"O.","family":"Reiter","sequence":"first","affiliation":[{"name":"Dermatology Service Memorial Sloan Kettering Cancer Center  New York NY USA"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv 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