{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:22:14Z","timestamp":1781112134239,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005205","name":"Janssen Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is a chronic immune\u2010mediated inflammatory skin disease that often leads to a diminished quality of life. Goals of treating patients with psoriasis have shifted with more focus on achieving near or complete clearance of the skin. Guselkumab, a fully human monoclonal antibody targeting interleukin\u201023, is effective in treating moderate\u2010to\u2010severe psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the baseline characteristics of patients with moderate\u2010to\u2010severe psoriasis achieving super\u2010response (Psoriasis Area and Severity Index [PASI] 100 response at Weeks 20 and 28) after commencing guselkumab treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pooled data from VOYAGE 1 and VOYAGE 2 studies identified super\u2010response; baseline demographic, disease and pharmacokinetic characteristics were compared with non\u2010super\u2010response. A stepwise logistic regression analysis identified which factors were potentially predictive of super\u2010response status, with significance level of 0.1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A subset of patients randomized to guselkumab comprised this <jats:italic>post hoc<\/jats:italic> analysis (<jats:italic>n<\/jats:italic>\u2009=\u2009664); 271 patients achieved super\u2010response vs. 393 with non\u2010super\u2010response. Patient age at study entry and baseline body weight (\u226490\u2009kg vs. &gt;90\u2009kg), PASI, and Investigator's Global Assessment (IGA) score were significant predictors of super\u2010response status, with odds ratios (95% confidence intervals) of 0.98 (0.967\u20130.993; <jats:italic>P<\/jats:italic>\u2009=\u20090.003), 1.42 (1.026\u20131.977; <jats:italic>P<\/jats:italic>\u2009=\u20090.034), 0.97 (0.955\u20130.993; <jats:italic>P<\/jats:italic>\u2009=\u20090.007) and 0.66 (0.433\u20130.997; <jats:italic>P<\/jats:italic>\u2009=\u20090.048), respectively. More patients with super\u2010response achieved an early response: Week 2 PASI 75 (5.5% vs. 1.8%) and Week 8 PASI 100 (22.5% vs. 3.3%) vs. non\u2010super\u2010response. Median serum guselkumab concentrations through Week 28 were slightly greater in patients with super\u2010response vs. non\u2010super\u2010response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Guselkumab was more likely to achieve early clinical responses (complete skin clearance) in younger patients, less obese patients and patients with less severe psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18474","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T14:28:38Z","timestamp":1659536918000},"page":"2393-2400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Super\u2010response to guselkumab treatment in patients with moderate\u2010to\u2010severe psoriasis: age, body weight, baseline Psoriasis Area and Severity Index, and baseline Investigator's Global Assessment scores predict complete skin clearance"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5248-4332","authenticated-orcid":false,"given":"K.","family":"Reich","sequence":"first","affiliation":[{"name":"Translational Research in Inflammatory Skin Diseases, Institute for Health Services Research in Dermatology and Nursing University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.B.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin  Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8394-2057","authenticated-orcid":false,"given":"B.","family":"Strober","sequence":"additional","affiliation":[{"name":"Yale University  New Haven CT USA"},{"name":"Central Connecticut Dermatology Research  Cromwell CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.G.","family":"Langley","sequence":"additional","affiliation":[{"name":"Dalhousie University  Halifax NS Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Miller","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development, LLC  Spring House PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010W.","family":"Yang","sequence":"additional","affiliation":[{"name":"Immunology Global Medical Affairs Janssen Pharmaceutical Companies of Johnson &amp; Johnson, LLC  Horsham PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010K.","family":"Shen","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development, LLC  Spring House PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"You","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development, LLC  Spring House PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development, LLC  Spring House PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Foley","sequence":"additional","affiliation":[{"name":"The University of Melbourne St. Vincent's Hospital Melbourne  Fitzroy VIC Australia"},{"name":"Probity Medical Research Inc. Skin Health Institute  Carlton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2633-985X","authenticated-orcid":false,"given":"A.","family":"Blauvelt","sequence":"additional","affiliation":[{"name":"Oregon Medical Research Center  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1590"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2018.1468252"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12118"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-015-1613-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1080-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2020.4957"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501646"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.01.025"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1497"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3895"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14175"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804595"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.041"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.042"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14910"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-049822"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.02.018"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.03.026"},{"key":"e_1_2_7_20_1","unstructured":"LiuX BraniganP ChenYet\u2009al.Identification of clinical and biomarker parameters associated with long\u2010term maintenance of PASI 90 response following guselkumab treatment withdrawal in psoriasis. 27thAnnual European Academy of Dermatology and Venereology Congress. 12\u201316 September 2018. 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