{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:51:47Z","timestamp":1793242307494,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004095","name":"Kyowa Hakko Kirin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>ABSTRCT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Brentuximab vedotin (BV) has been approved for CD30\u2010expressing cutaneous T\u2010cell lymphoma (CTCL) after at least one previous systemic treatment. However, real clinical practice is still limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the response and tolerance of BV in a cohort of patients with CTCL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed CTCL patients treated with BV from the Spanish Primary Cutaneous Lymphoma Registry (RELCP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010seven patients were included. There were 26 females and the mean age at diagnosis was 59\u2009years. Forty\u2010eight were mycosis fungoides (MF), 7 S\u00e9zary syndrome (SS) and 12 CD30+ lymphoproliferative disorders (CD30 LPD). Mean follow\u2010up was 18\u2009months. Thirty patients (45%) showed at least 10% of CD30+ cells among the total lymphocytic infiltrate. The median number of BV infusions received was 7. The overall response rate (ORR) was 67% (63% in MF, 71% in SS and 84% in CD30 LPD). Ten of 14 patients with folliculotropic MF (FMF) achieved complete or partial response (ORR 71%). The median time to response was 2.8\u00a0months. During follow\u2010up, 36 cases (54%) experienced cutaneous relapse or progression. The median progression free survival (PFS) was 10.3\u00a0months. The most frequent adverse event was peripheral neuropathy (PN) (57%), in most patients (85%), grades 1 or 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results confirm the efficacy and safety of BV in patients with advanced\u2010stage MF, and CD30 LPD. In addition, patients with FMF and SS also showed a favourable response. Our data suggest that BV retreatment is effective in a proportion of cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.18563","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T05:31:16Z","timestamp":1661491876000},"page":"57-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Brentuximab vedotin in the treatment of cutaneous T\u2010cell lymphomas: Data from the Spanish Primary Cutaneous Lymphoma Registry"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0703-943X","authenticated-orcid":false,"given":"Cristina","family":"Muniesa","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitari de Bellvitge, Universitat de Barcelona, IDIBELL, L'Hospitalet de Llobregat  Barcelona Spain"},{"name":"Department of Dermatology Hospital de Viladecans  Viladecans, Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar, IMAS\u2010IMIM  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-5260","authenticated-orcid":false,"given":"Ignacio","family":"Garc\u00eda\u2010Doval","sequence":"additional","affiliation":[{"name":"Research Unit Fundaci\u00f3n Piel Sana AEDV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Teresa","family":"Estrach","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital Cl\u00ednic Universitat de Barcelona, IDIBAPS  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Combalia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital Cl\u00ednic Universitat de Barcelona, IDIBAPS  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Morillo\u2010And\u00fajar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario V\u00edrgen del Roc\u00edo  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"De la Cruz\u2010Vicente","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitario V\u00edrgen del Roc\u00edo. Instituto de Biomedicina de Sevilla (IBIS)\/CSIC\/Universidad de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-7547","authenticated-orcid":false,"given":"Salma","family":"Machan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0394-1282","authenticated-orcid":false,"given":"Cristina","family":"Moya\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Rovira","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar, IMAS\u2010IMIM  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Sanchez\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital del Mar, IMAS\u2010IMIM  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Acebo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Cruces  Barakaldo Bizkaia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Amutio","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitario de Cruces  Barakaldo Bizkaia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-6982","authenticated-orcid":false,"given":"Yeray","family":"Pe\u00f1ate","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario Universitario Insular Materno\u2010Infantil, Las Palmas de Gran  Canaria, Las Palmas Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria del Carmen","family":"Losada\u2010Castillo","sequence":"additional","affiliation":[{"name":"Department of Hematology Complejo Hospitalario Universitario Insular Materno\u2010Infantil, Las Palmas de Gran  Canaria, Las Palmas Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Pilar","family":"Garc\u00eda\u2010Muret","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0710-5521","authenticated-orcid":false,"given":"Helena","family":"Iznardo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Rom\u00e1n\u2010Curto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Salamanca  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-7353","authenticated-orcid":false,"given":"Javier","family":"Ca\u00f1ueto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Salamanca  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4120-9962","authenticated-orcid":false,"given":"Ricardo","family":"Fern\u00e1ndez\u2010de\u2010Misa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Nuestra Se\u00f1ora de Candelaria  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngeles","family":"Fl\u00f3rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario Universitario de Pontevedra  Pontevedra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Mar\u00eda","family":"Izu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de Basurto  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Torres\u2010Navarro","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Zayas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Dr Peset  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"P\u00e9rez\u2010Paredes","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Blanes","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Alicante, Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante (ISABIAL)  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Ignacio","family":"Yanguas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Navarra  Pamplona, Navarra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"P\u00e9rez\u2010Ferriols","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Callejas\u2010Charavia","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Pr\u00edncipe de Asturias  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Luis","family":"Ortiz\u2010Romero","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario 12 de Octubre, Institute I+12 Research Institute, Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"P\u00e9rez\u2010Gil","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario V\u00edrgen de Valme  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Prieto\u2010Torres","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Lozano Blesa  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gonz\u00e1lez\u2010Barca","sequence":"additional","affiliation":[{"name":"Department of Hematology Institut Catal\u00e0 d'Oncologia, Hospital Duran i Reynals, IDIBELL, L'Hospitalet de LLobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9910-9617","authenticated-orcid":false,"given":"Octavio","family":"Servitje","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari de Bellvitge, Universitat de Barcelona, IDIBELL, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31266-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.3969"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.3787"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-881268"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-054601"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-055749"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012057"},{"key":"e_1_2_9_9_1","first-page":"610","article-title":"The first year of the AEVD primary cutaneous lymphoma registry","volume":"109","author":"Pe\u00f1ate Y","year":"2018","journal-title":"Actas Dermosifiliogr"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20588"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16052"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17254"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.3961"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/ddg.14675","article-title":"Long term survival, time to next treatment and CD30 expression in patients with advanced CD30+ cutaneous T\u2010cell lymphoma treated with Brentuximab vedotin \u2013 A monocentric retrospective analysis of twelve patients","volume":"20","author":"Gosmann J","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20786"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.3593"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.4901"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-01197-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18806"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18535"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.01.054"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18563","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.18563","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:29:34Z","timestamp":1692674974000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.18563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,9]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/jdv.18563"],"URL":"https:\/\/doi.org\/10.1111\/jdv.18563","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742294504.793595067","asserted-by":"object"}]},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,9]]},"assertion":[{"value":"2022-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}