{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:14:25Z","timestamp":1785798865766,"version":"3.56.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017655","name":"Incyte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ruxolitinib cream is a topical formulation of ruxolitinib, a Janus kinase (JAK) 1\/JAK2 inhibitor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report timing and magnitude of effect of ruxolitinib cream on itch in patients with atopic dermatitis (AD), a highly pruritic inflammatory skin disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two phase 3 trials (TRuE\u2010AD1 [NCT03745638]\/TRuE\u2010AD2 [NCT03745651]) enrolled patients aged \u226512\u2009years with AD for \u22652\u2009years, Investigator's Global Assessment score of 2 or 3, and 3%\u201320% affected body surface area. Patients (total <jats:italic>N<\/jats:italic>\u00a0=\u20091249; median age, 32\u2009years) were randomised (2:2:1) to twice daily 0.75% ruxolitinib cream, 1.5% ruxolitinib cream or vehicle cream for 8\u2009weeks of double\u2010blinded treatment. Worst itch was measured using the numerical rating scale (NRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly more patients who applied ruxolitinib cream (either strength) achieved a \u22652\u2010point itch reduction (NRS2) within approximately 12\u2009h versus vehicle (0.75%\/1.5% ruxolitinib cream, 16.3%\/13.1%; vehicle, 6.9%; both <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.05), with further improvements through Week 8 (58.3%\/65.1% vs 29.4%; both <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.0001). A \u22654\u2010point itch reduction (NRS4) was achieved by significantly more patients who applied 0.75%\/1.5% ruxolitinib cream versus vehicle by Day 2 (8.9%\/11.2% vs 2.1%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.005); higher rates were observed at Week 8 (41.5%\/51.5% vs 15.8%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.0001). Median time for the 0.75%\/1.5% ruxolitinib cream groups to achieve NRS4 from baseline was 15.0\/13.0\u2009days; this endpoint was not reached by the vehicle group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ruxolitinib cream demonstrated rapid improvement in itch in patients with mild to moderate AD that was sustained for 8\u2009weeks. Significantly more patients applying ruxolitinib cream achieved itch NRS2 within approximately 12\u2009h and itch NRS4 by Day 2 versus vehicle.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18571","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T13:28:25Z","timestamp":1662470905000},"page":"137-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Rapid pruritus reduction with ruxolitinib cream treatment in patients with atopic dermatitis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2633-985X","authenticated-orcid":false,"given":"Andrew","family":"Blauvelt","sequence":"first","affiliation":[{"name":"Oregon Medical Research Center  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Kircik","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9557-3642","authenticated-orcid":false,"given":"Kim A.","family":"Papp","sequence":"additional","affiliation":[{"name":"K. Papp Clinical Research and Probity Medical Research  Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3686-7805","authenticated-orcid":false,"given":"Jonathan\u00a0I.","family":"Silverberg","sequence":"additional","affiliation":[{"name":"George Washington University  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3736-1515","authenticated-orcid":false,"given":"Shawn 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