{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:49:59Z","timestamp":1790736599641,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Scabies is an itchy, parasitic infection of the skin. Recent reports indicate there is a decreasing efficacy of the standard treatment of choice, topical 5% permethrin cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the comparative efficacy, safety and tolerability of topical benzyl benzoate (BB) with oral ivermectin in the treatment of scabies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with dermoscopy\u2010verified scabies visiting the dermatologic outpatient clinic were assessed for enrolment in the study. In total, 224 patients were enrolled and sequentially randomized into two equally sized groups. Group A received topical 25% or 10% BB for the daily use over a period of three consecutive days, group B received oral ivermectin (200\u2009\u03bcg\/kg body weight) twice, 1\u2009week apart. Treatment outcome was evaluated by dermoscopy at a 3\u2010week follow\u2010up visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment resulted in a cure rate of 87% in group A and 86% in group B. After initial therapy failure in group A, six out of eight patients showed treatment response upon repeated application of BB, five of five when retreated with ivermectin and two of two with BB plus ivermectin, respectively. In group B, successful retreatment was observed in three out of three patients with ivermectin, two of two patients with BB and 11 of 11 patients with the combination of BB plus ivermectin, respectively. Tolerability and safety profile of oral ivermectin was excellent, while BB produced short burning sensations in 14%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical BB and oral ivermectin have shown comparable good therapeutic efficacy. Therefore, both agents constitute an adequate first\u2010line therapy in the treatment of scabies. A combination of both agents may be considered in recalcitrant and extensively infested cases, additionally to crusted scabies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18573","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T02:09:18Z","timestamp":1663034958000},"page":"160-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Comparison of topical benzyl benzoate vs. oral ivermectin in treating scabies: A randomized study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8339-6917","authenticated-orcid":false,"given":"Damian","family":"Meyersburg","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Salzburg of the Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3159-0720","authenticated-orcid":false,"given":"Tobias","family":"Welponer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Salzburg of the Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Inpatient Psychotherapy, University Hospital of Psychiatry and Psychotherapy Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Selhofer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Salzburg of the Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaella","family":"Tatarski","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Salzburg of the Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9823-7644","authenticated-orcid":false,"given":"Alessandra","family":"Handisurya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes Wolfgang","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Salzburg of the Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006996"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14351"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13130"},{"key":"e_1_2_14_5_1","unstructured":"\u00d6sterreichische Gesellschaft f\u00fcr Sexually Transmitted Diseases und dermatologische Mikrobiologie: Skabies Therapiemanagement f\u00fcr Allgemeinmediziner und Fach\u00e4rzte. Addendum zur Version 11\/2019. Available from:http:\/\/www.oegstd.at\/"},{"key":"e_1_2_14_6_1","first-page":"1","article-title":"Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015","volume":"64","author":"Workowski KA","year":"2015","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68772-2"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1774489"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13706"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17339"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.2217\/17460913.3.1.57"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0983-z"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1994.tb125968.x"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-3-43"},{"key":"e_1_2_14_15_1","unstructured":"Statistik Austria.Geborene nach ausgew\u00e4hlten demografischen und medizinischen Merkmalen seit 2009. [cited 2021 Apr]. Available from:https:\/\/www.statistik.at\/web_de\/statistiken\/menschen_und_gesellschaft\/bevoelkerung\/geborene\/022899.html"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14209"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18943"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2915.2008.00716.x"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17348"},{"key":"e_1_2_14_20_1","article-title":"Ivermectin and permethrin for treating scabies","volume":"4","author":"Rosumeck S","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-314505"},{"key":"e_1_2_14_22_1","first-page":"757","article-title":"The Treatment of Scabies\u2010a systematic review of randimized controlled trials","volume":"113","author":"Dressler C","year":"2016","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_14_23_1","article-title":"Interventions for treating scabies","volume":"2007","author":"Strong M","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2008.513"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct0910329"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.08.052308"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.48882"},{"key":"e_1_2_14_28_1","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/ddg.14122","article-title":"Application errors associated with topical treatment of scabies: an observational study","volume":"18","author":"Nemecek R","year":"2020","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18369"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.18573","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T07:29:50Z","timestamp":1692689390000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.18573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,23]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/jdv.18573"],"URL":"https:\/\/doi.org\/10.1111\/jdv.18573","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,23]]},"assertion":[{"value":"2021-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}