{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:08:23Z","timestamp":1787242103799,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although chronic urticaria (CU) is a common and primarily affects females, there is little data on how pregnancy interacts with the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyse the treatment use by CU patients before, during and after pregnancy as well as outcomes of pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PREG\u2010CU is an international, multicentre study of the Urticaria Centers of Reference and Excellence network. Data were collected via a 47\u2010item\u2010questionnaire completed by CU patients who became pregnant during their disease course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Questionnaires from 288 CU patients from 13 countries were analysed. During pregnancy, most patients (60%) used urticaria medication including standard\u2010dose second generation H1\u2010antihistamines (35.1%), first generation H1\u2010antihistamines (7.6%), high\u2010dose second\u2010generation H1\u2010antihistamines (5.6%) and omalizumab (5.6%). The preterm birth rate was 10.2%; rates were similar between patients who did and did not receive treatment during pregnancy (11.6% vs. 8.7%, respectively). Emergency referrals for CU and twin birth were risk factors for preterm birth. The caesarean delivery rate was 51.3%. More than 90% of new\u2010borns were healthy at birth. There was no link between any patient or disease characteristics or treatments and medical problems at birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Most CU patients used treatment during pregnancy especially second\u2010generation antihistamines which seem to be safe during pregnancy regardless of the trimester. The rates of preterm births and medical problems of new\u2010borns in CU patients were similar to population norms and not linked to treatment used during pregnancy. Emergency referrals for CU increased the risk of preterm birth and emphasize the importance of sufficient treatment to keep urticaria under control during pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.18574","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T12:09:21Z","timestamp":1662466161000},"page":"356-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Treatment patterns and outcomes in patients with chronic urticaria during pregnancy: Results of\n                    <scp>PREG\u2010CU<\/scp>\n                    , a\n                    <scp>UCARE<\/scp>\n                    study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2801-0959","authenticated-orcid":false,"given":"Emek","family":"Kocat\u00fcrk","sequence":"first","affiliation":[{"name":"Department of Dermatology, Urticaria Center of Reference, and Excellence (UCARE) Ko\u00e7 University School of Medicine  Istanbul Turkey"},{"name":"Institute of Allergology, Urticaria Center of Reference and Excellence (UCARE) Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Allergology and Immunology Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Al\u2010Ahmad","sequence":"additional","affiliation":[{"name":"Microbiology Department, Faculty of Medicine, Urticaria Center of Reference, and Excellence (UCARE) Kuwait University  Safat Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9711-9654","authenticated-orcid":false,"given":"Karoline","family":"Krause","sequence":"additional","affiliation":[{"name":"Institute of Allergology, Urticaria Center of Reference and Excellence (UCARE) Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Allergology and Immunology Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5434-7753","authenticated-orcid":false,"given":"Ana M.","family":"Gimenez\u2010Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Urticaria Center of Reference, and Excellence (UCARE), Hospital del Mar, IMIM Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Francis","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Urticaria Center of Reference, and Excellence (UCARE) Bispebjerg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall","family":"Conlon","sequence":"additional","affiliation":[{"name":"Department of Immunology, Urticaria Center of Reference and Excellence (UCARE), St. James's Hospital Dublin and Trinity College  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Marsland","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Urticaria Center of Reference, and Excellence (UCARE), The Urticaria Clinic, Salford Royal Foundation Trust University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9318-1378","authenticated-orcid":false,"given":"Ekin","family":"Savk","sequence":"additional","affiliation":[{"name":"Ayd\u0131n Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta F.","family":"Criado","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Urticaria Center of Reference and Excellence (UCARE) Faculdade de Medicina do ABC (FMABC)  Santo Andr\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Danilycheva","sequence":"additional","affiliation":[{"name":"NRC Institute of Immunology, FMBA of Russia  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Fomina","sequence":"additional","affiliation":[{"name":"First Moscow State Medical University  Moscow Russia"},{"name":"Urticaria Center of Reference and Excellence (UCARE), Moscow Center of Allergy and Immunology, Clinical Hospital 52 Ministry of Moscow Healthcare  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Godse","sequence":"additional","affiliation":[{"name":"Dr. D.Y. Patil Medical College &amp; Hospital  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Khoshkhui","sequence":"additional","affiliation":[{"name":"Allergy Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131","family":"Gelincik","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ece Nur","family":"Degirmentepe","sequence":"additional","affiliation":[{"name":"Okmeydani Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semra","family":"Demir","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Istanbul University  Istanbul 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University of Rio de Janeiro  Rio De Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Medina","sequence":"additional","affiliation":[{"name":"The Centro M\u00e9dico Vitae  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Allergy Center, University Hospital Carl Gustav Carus Technical University Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuotao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses and National Clinical Research Center for Skin and Immune Diseases Peking University First Hospital  Beijing 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