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Our objective was to assess melanoma risk in patients with CMN of all size categories. A literature review with meta\u2010analysis was performed. Prevalence and incidence densities of melanoma at onset were calculated in the entire study population and according to CMN size, type of treatment and location of the CMN. A total of 91 melanomas were reported in 7915 patients (1.15%, 95% CI, 0.93\u20131.41). The overall incidence density was 0.057% person\u2010years (95% CI<jats:sub>,<\/jats:sub> 0.044\u20130.071). The risk ratio of melanoma incidence densities was 21.9 (95% CI, 8.55\u201356.3) in large to giant CMN compared with small to medium CMN at 15\u2009years of age. The incidence density was higher in CMN located on the trunk and as well as in those which were untreated or partially treated versus complete excision. Our review suggests patients with CMN of medium, large and giant size are at risk of melanoma, whereas the risk remains unknown for small CMN.<\/jats:p>","DOI":"10.1111\/jdv.18581","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T14:54:01Z","timestamp":1663944841000},"page":"32-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Risk of melanoma in congenital melanocytic nevi of all sizes: A systematic review"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5679-2260","authenticated-orcid":false,"given":"Camille","family":"Scard","sequence":"first","affiliation":[{"name":"Department of Dermatology CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-9900","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Aubert","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Wargny","sequence":"additional","affiliation":[{"name":"CHU de Nantes INSERM, CIC 1413, P\u00f4le Hospitalo\u2010Universitaire 11: Sant\u00e9 Publique, Clinique des Donn\u00e9es  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Angers  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6629-9100","authenticated-orcid":false,"given":"Sebastien","family":"Barbarot","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Nantes  Nantes France"},{"name":"UMR 1280 PhAN, INRA Nantes Universit\u00e9  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.05.043"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.02.052"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1981.tb00954.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/360590"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30966-X"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06316.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890260072011"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200502000-00010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2012.03.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70319-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_9_13_1","unstructured":"Ottawa Hospital Research Institute. 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