{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:24:13Z","timestamp":1788395053644,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although leg ulcers are a burdensome disease most common in those aged 65\u2009years and older, frailty in this population has not yet been well established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to prospectively explore and compare the presence of frailty in elderly patients with chronic leg or foot ulcers by applying different validated frailty screening methods in three healthcare settings and to assess the feasibility of frailty screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared frailty of leg ulcer patients referred to an academic hospital with a non\u2010academic hospital, leg ulcer patients receiving (primary) homecare, and a dermato\u2010oncology patient population (control group). Frailty and quality of life were assessed using four validated questionnaires: the Groninger Frailty Indicator, Geriatric\u20108, Mini\u2010Cog and Wound Quality of Life. To analyse data multiple (non)\u2010parametric tests were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty of 60 included leg ulcer patients (83%) scored \u201cfrail\u201d on at least one frailty questionnaire (GFI, G8 or Mini\u2010Cog). The number of patients scoring \u201cfrail\u201d on two or three out of three applied frailty questionnaires were significantly higher in the academic and homecare ulcer population compared with the non\u2010academic ulcer population and control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). In the academic ulcer population mean Wound Quality of Life scores were 30.2 (SD 17.6), compared with 17.7 (SD 13.1) in the non\u2010academic and 15.0 (SD 10.4) in the homecare ulcer population (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of patients suffering from leg ulcers in this study was frail. The highest frailty prevalence was observed in the academic and homecare ulcer populations. The largest impaired quality of life was reported in the academic ulcer population. In dermatology practice, implementing frailty screening and initiating appropriate (paramedical) supportive care should be considered to improve patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18586","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T14:03:30Z","timestamp":1664028210000},"page":"428-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A prospective, multicentre study to assess frailty in elderly patients with leg ulcers (<scp>GERAS<\/scp>study)"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-5055","authenticated-orcid":false,"given":"Nadja E.","family":"Zorge","sequence":"first","affiliation":[{"name":"Department of Dermatology Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1688-7107","authenticated-orcid":false,"given":"Eveline R. Y.","family":"Scheerders","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4168-2311","authenticated-orcid":false,"given":"Koen","family":"Dudink","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-0344","authenticated-orcid":false,"given":"Christian","family":"Oudshoorn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7458-725X","authenticated-orcid":false,"given":"Harmke A.","family":"Polinder\u2010Bos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6163-9164","authenticated-orcid":false,"given":"Rick","family":"Waalboer\u2010Spuij","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Schlejen","sequence":"additional","affiliation":[{"name":"Department of Surgery Groene Hart Ziekenhuis Gouda The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1638-3929","authenticated-orcid":false,"given":"Catherine","family":"van Montfrans","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12387"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129334-200311000-00013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040797"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.016782"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.11.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03553.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02456.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800810206"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-016-0198-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.04.049"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12193"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53405.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.04054.x"},{"key":"e_1_2_9_16_1","first-page":"36","volume-title":"WHO clinical consortium on healthy ageing. 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