{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:34:35Z","timestamp":1791858875205,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["21 1486 Pj"],"award-info":[{"award-number":["21 1486 Pj"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["20 0156 F"],"award-info":[{"award-number":["20 0156 F"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007232","name":"Radiumhemmets Forskningsfonder","doi-asserted-by":"publisher","award":["194092"],"award-info":[{"award-number":["194092"]}],"id":[{"id":"10.13039\/501100007232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","award":["20200638"],"award-info":[{"award-number":["20200638"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inherited mutations in the <jats:italic>CDKN2A<\/jats:italic> gene are among the strongest known risk factors for cutaneous melanoma. Further, previous studies have reported inferior melanoma\u2010specific survival in <jats:italic>CDKN2A<\/jats:italic> mutation carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Here, the melanoma\u2010specific survival was studied, depending on <jats:italic>CDKN2A<\/jats:italic> carrier status and if the melanomas had been diagnosed before or after families were included in a surveillance program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Melanoma\u2010prone families participating in this study were identified through a nationwide preventive program starting in 1987. Information on melanoma tumours and deaths was obtained through the Swedish Cancer Registry and Cause of Death Registry. Kaplan\u2013Meier and Cox proportional hazards regression models were used to assess melanoma\u2010specific survival in four defined cohorts, <jats:italic>CDKN2A<\/jats:italic> mutation (MUT) carriers with first invasive melanoma before or after inclusion [<jats:italic>MUT\u2010pre<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a053) and <jats:italic>MUT\u2010post<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a043)] and likewise in <jats:italic>CDKN2A<\/jats:italic> wild type (WT) cases [<jats:italic>WT\u2010pre<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0255) and <jats:italic>WT\u2010post<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0122)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic>MUT\u2010pre<\/jats:italic> and <jats:italic>MUT\u2010post<\/jats:italic> cases were diagnosed with their first invasive melanoma at a significantly younger ages (38 and 42\u2009years, respectively) than the <jats:italic>WT\u2010pre<\/jats:italic> and <jats:italic>WT\u2010post<\/jats:italic> cases (48 and 57\u2009years, respectively). The melanomas in the <jats:italic>MUT\u2010pre<\/jats:italic> had significantly higher T stage compared with <jats:italic>MUT\u2010post<\/jats:italic> (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006), whereas no such difference was seen comparing <jats:italic>WT\u2010pre<\/jats:italic> with <jats:italic>WT\u2010post<\/jats:italic> (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.849). <jats:italic>MUT\u2010pre<\/jats:italic> had compared with <jats:italic>WT\u2010pre<\/jats:italic>, significantly worse melanoma\u2010specific survival, unadjusted (HR 2.33, 95% CI 1.33\u20134.08, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003) adjusted (HR 2.70, 95% CI 1.46\u20135.00, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). However, the <jats:italic>MUT\u2010post<\/jats:italic> cases had compared with the <jats:italic>WT\u2010post<\/jats:italic> cases, no significant survival differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study is the first to address the impact on survival from introducing a dermatologic surveillance program to familial melanoma cases with or without <jats:italic>CDKN2A<\/jats:italic> mutations. The <jats:italic>CDKN2A<\/jats:italic>\u2010mut carriers appeared to have a clear benefit with less advanced melanomas diagnosed and better melanoma\u2010specific survival after inclusion. Among the <jats:italic>CDKN2A<\/jats:italic>\u2010wt cases, the effect of the inclusion on the studied outcomes was less evident.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18589","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T12:59:24Z","timestamp":1664197164000},"page":"284-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Melanoma\u2010specific survival before and after inclusion in a familial\u00a0melanoma dermatologic surveillance program in <scp><i>CDKN2A<\/i><\/scp> mutation carriers and non\u2010carriers"],"prefix":"10.1111","volume":"37","author":[{"given":"Maria","family":"Pissa","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Ryhov County Hospital  J\u00f6nk\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-8959","authenticated-orcid":false,"given":"Jan","family":"Lapins","sequence":"additional","affiliation":[{"name":"Department of Medicine, Unit of Dermatology Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Dermatology, Skin Cancer Center Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Sk\u00f6ldmark","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Ryhov County Hospital  J\u00f6nk\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0735-4771","authenticated-orcid":false,"given":"Hildur","family":"Helgadottir","sequence":"additional","affiliation":[{"name":"Department of Oncology and Pathology Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Oncology, Skin Cancer Center Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.04.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200404000-00007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-008158"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13403"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.5415"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.02704.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.4108"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.3884"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.5651"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.12.894"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2014-102320"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.05.050"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.5624"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.187"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510123331504"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29595"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2008.00526.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq363"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.270"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.044"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.272"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.11.014"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200212000-00004"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw135"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.06.138"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2021.1914346"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.10.024"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.060"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910836"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1904059"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2018-105610"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2018-105610"},{"key":"e_1_2_9_34_1","first-page":"6864","article-title":"CDKN2A germ\u2010line mutations in individuals with multiple cutaneous melanomas","volume":"60","author":"Hashemi J","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.10.697"},{"key":"e_1_2_9_36_1","unstructured":"Yearly report of the Swedish Melanoma Registry (SweMR) 1990\u20132020. [Accessed 2021 Jan 7]. Available from:https:\/\/cancercentrum.se\/globalassets\/om\u2010rcc\/sydost\/pdf\/swemr\u20101990\u20102020.pdf"},{"key":"e_1_2_9_37_1","first-page":"892","article-title":"[Older people with melanoma seek care late and have a higher mortality]","volume":"114","author":"Nielsen K","year":"2017","journal-title":"Lakartidningen"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1521"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.03.014"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30925"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18589","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.18589","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T13:42:11Z","timestamp":1692711731000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.18589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/jdv.18589"],"URL":"https:\/\/doi.org\/10.1111\/jdv.18589","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"2022-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}