{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:21:05Z","timestamp":1768972865288,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1093017"],"award-info":[{"award-number":["APP1093017"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1141295"],"award-info":[{"award-number":["APP1141295"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little guidance is currently available for managing patients with melanocytic tumours of uncertain or low malignant potential (MelTUMPs, including melanocytomas), in particular the optimal excision margins and whether to offer sentinel node biopsy (SNB). The objective of this review was to evaluate excision margins and the prognostic utility of SNB by systematic review of the literature and meta\u2010analysis. PRISMA guidelines were followed. Medline, EMBASE and Cochrane databases were searched to October 2021 for studies of patients with MelTUMPs reporting excision margins and\/or SNB\u2010positivity. Meta\u2010analysis was performed on the SNB\u2010positivity rate using a random effects model, followed by sensitivity analyses on subgroups. 111 primary studies reported excision margins and\/or SNB data for 1962 patients. Follow\u2010up was available for 1649 patients: 1561 (94.7%) were alive without disease at last review, 53 (3.2%) had developed further disease, 29 (1.8%) had died of metastatic disease (melanoma) and six (0.4%) died of unrelated causes. SNB was performed in 837 patients. The pooled positivity rate on meta\u2010analysis was 32% (95% CI: 23\u201344%). Clinical outcome could be correlated with excision margin in only 171 patients (60% of those with known follow up) and was therefore not analysed further. Evidence indicating the ideal excision margins for MelTUMPs was lacking. SNB had a high positivity rate despite very low rates of recurrence or melanoma\u2010related death. Consequently, SNB should not be offered routinely for MelTUMPs (including melanocytomas), due to its lack of prognostic utility for this tumour type (high certainty of evidence).<\/jats:p>","DOI":"10.1111\/jdv.18665","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T15:53:30Z","timestamp":1666022010000},"page":"859-870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical management of melanocytic tumours of uncertain malignant potential (<scp>MelTUMPs<\/scp>), including melanocytomas: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7665-8015","authenticated-orcid":false,"given":"Alexander H. R.","family":"Varey","sequence":"first","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  North Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  New South Wales Sydney Australia"},{"name":"Department of Plastic and Maxillofacial Surgery Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9240-3648","authenticated-orcid":false,"given":"Gabrielle J.","family":"Williams","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  North Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-5544","authenticated-orcid":false,"given":"Serigne N.","family":"Lo","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  North Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  New South Wales Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia Y.","family":"Taing","sequence":"additional","affiliation":[{"name":"Cancer Council Australia  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-5373","authenticated-orcid":false,"given":"Andrea","family":"Maurichi","sequence":"additional","affiliation":[{"name":"Melanoma and Sarcoma Surgical Unit Fondazione IRCCS Instituto Nazionale dei Tumori  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8436-4757","authenticated-orcid":false,"given":"Mario","family":"Santinami","sequence":"additional","affiliation":[{"name":"Melanoma and Sarcoma Surgical Unit Fondazione IRCCS Instituto Nazionale dei Tumori  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8991-0013","authenticated-orcid":false,"given":"Richard A.","family":"Scolyer","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  North Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  New South Wales Sydney Australia"},{"name":"Tissue Pathology and Diagnostic Oncology Royal Prince Alfred Hospital and NSW Health Pathology  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2816-2496","authenticated-orcid":false,"given":"John F.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  North Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  New South Wales Sydney Australia"},{"name":"Department of Melanoma and Surgical Oncology Royal Prince Alfred Hospital  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cf7fa0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.042"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-21619-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1043\/2010\u20100146\u2010ra.1"},{"key":"e_1_2_10_6_1","first-page":"470","volume-title":"WHO classification of skin tumours","author":"Elder DE","year":"2018"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(13)70608\u20109"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.016"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2013.17"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000444701.62990.71"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm-2017-110853"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-7-10"},{"key":"e_1_2_10_13_1","volume-title":"The Newcastle\u2010Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses","author":"Peterson J","year":"2011"},{"key":"e_1_2_10_14_1","unstructured":"IBM Corp.Released 2016. 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