{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:14:08Z","timestamp":1792030448669,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rosacea is a common chronic inflammatory facial skin disorder. Standardized evaluation of the severity and extent of rosacea is important for baseline assessment and treatment effect. The currently used Investigator's Global Assessment (IGA) is unspecific and fails to consider subtypes\/phenotypes of rosacea and area involvement. The Rosacea Area and Severity Index (RASI) was developed to give a more nuanced evaluation of rosacea features in four facial skin areas adjusted to the relative importance of each area of the face to obtain an overall severity score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To validate RASI against the IGA and to assess the inter\u2010 and intraobserver reliability for RASI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixteen dermatologists evaluated photographs of 60 adult patients with rosacea (3 photographs per patient, one from the front and one from each side). IGA and RASI scores were performed for interobserver reliability assessment. To determine intraobserver reliability, 14 dermatologists evaluated 10 other patients twice with at least 1\u2009week interval.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The IGA and RASI correlated well (Spearman correlation coefficient (SCC)\u00a0=\u00a00.75, 95% confidence interval (CI)\u00a0=\u00a00.72\u20130.78). Interobserver reliability was moderate for RASI and poor to moderate for IGA. Reliability was strongest for rhinophyma, followed by papules\/pustules and erythema, and rather weak for telangiectasia. For area scores, interobserver reliability was strongest for cheeks, followed by nose, chin and forehead. We found a moderate\u2010to\u2010strong intraobserver agreement both for IGA and RASI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We have designed a new practical tool to examine clinical severity of rosacea. RASI proved simple and reliable in scoring clinical severity of rosacea with an agreement comparable to the currently used IGA although RASI will provide a more nuanced view of the current rosacea extent and severity. We suggest that RASI is used in the daily clinical setting as well as in clinical studies assessing the efficacy of rosacea therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.18721","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T11:18:18Z","timestamp":1667560698000},"page":"573-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Validity and reliability of the Rosacea Area and Severity Index: A novel scoring system for clinical assessment of rosacea severity"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3243-0796","authenticated-orcid":false,"given":"Nita Katarina Frifelt","family":"Wienholtz","sequence":"first","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Neurology, Danish Headache Center Copenhagen University Hospital \u2013 Rigshospitalet Glostrup  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-1743","authenticated-orcid":false,"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper Emil","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center Copenhagen University Hospital \u2013 Rigshospitalet Glostrup  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Francis","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine Elisabeth","family":"Karmisholt","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor B. E.","family":"Jemec","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans B.","family":"Lomholt","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Heidenheim","sequence":"additional","affiliation":[{"name":"Gildh\u00f8j Privathospital Copenhagen  Br\u00f8ndby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Birgitte","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Sand","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venerology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diljit","family":"Kaur\u2010Knudsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Ammitzb\u00f8ll","sequence":"additional","affiliation":[{"name":"Hareskov Hudklinik  V\u00e6rl\u00f8se Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"L\u00f8rup","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne G.","family":"Danielsen","sequence":"additional","affiliation":[{"name":"Hudklinikken Panoptikon  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte","family":"Strauss","sequence":"additional","affiliation":[{"name":"Hudklinikken Panoptikon  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-9680","authenticated-orcid":false,"given":"Lone","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Hudl\u00e6ge i Vejle  Vejle 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