{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T20:59:12Z","timestamp":1784062752098,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Four posters about the novel, fixed\u2010dose calcipotriol and betamethasone dipropionate cream (CAL\/BDP cream) based on Poly\u2010Aphron Dispersion (PAD) Technology were presented at the 30<jats:sup>th<\/jats:sup> European Academy of Dermatology and Venereology (EADV) Congress 2021 and are summarized here. CAL\/BDP cream was compared in two randomized, phase 3 trials to vehicle and active comparator (CAL\/BDP gel\/topical suspension [TS]) in adults with plaque psoriasis (NCT03802344 and NCT03308799). Pooled data from both trials demonstrated significant greater efficacy in favour of CAL\/BDP cream for all efficacy endpoints, including PGA treatment success, mPASI, and mPASI75 compared to CAL\/BDP gel\/TS. CAL\/BDP cream was well tolerated and comparable to CAL\/BDP gel\/TS with no adverse drug reactions with a frequency &gt;1%. In the NCT03308799 study, CAL\/BDP cream demonstrated a substantial improvement in the proportion of participants achieving a minimum 4\u2010point improvement on the peak pruritus numeric rating scale (NRS) score compared with vehicle at Weeks 1, 4 and 8. CAL\/BDP cream also improved quality of life (QoL), as assessed through the Dermatology Life Quality Index (DLQI), and the EQ\u2010VAS at Week 8 compared with active comparator. Treatment convenience of CAL\/BDP cream, as measured by the Psoriasis Treatment Convenience Scale, was superior to CAL\/BDP gel\/TS at all studied timepoints, including questions addressing formulation's greasiness and overall treatment satisfaction. Finally, an indirect comparison following the Bucher's method of adjusted indirect comparison and the difference\u2010in\u2010differences method was conducted to compare CAL\/BDP cream and CAL\/BDP foam, as both therapies have been compared to CAL\/BDP gel\/TS. Indirect evidence showed that treatment with CAL\/BDP cream was associated with a trend for greater QoL improvement than CAL\/BDP foam when DLQI improvement was assessed at the recommended treatment duration of 8\u2009weeks for CAL\/BDP cream and 4\u2009weeks for CAL\/BDP foam. CAL\/BDP cream was statistically superior versus CAL\/BDP foam in four out of five treatment satisfaction domains.<\/jats:p>","DOI":"10.1111\/jdv.18755","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T10:48:03Z","timestamp":1671706083000},"page":"14-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A novel, fixed\u2010dose calcipotriol and betamethasone dipropionate cream for the topical treatment of plaque psoriasis: Direct and indirect evidence from phase 3 trials discussed at the 30<sup>th<\/sup><scp>EADV<\/scp> Congress 2021"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1330-1502","authenticated-orcid":false,"given":"Andreas","family":"Pinter","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Frankfurt am Main  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2758-1605","authenticated-orcid":false,"given":"Linda Stein","family":"Gold","sequence":"additional","affiliation":[{"name":"Dermatology Clinical Research Henry Ford Health System  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5573-1754","authenticated-orcid":false,"given":"Adam","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Rzesz\u00f3w  Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1295-9249","authenticated-orcid":false,"given":"Lawrence J.","family":"Green","sequence":"additional","affiliation":[{"name":"George Washington University School of Medicine  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2413-791X","authenticated-orcid":false,"given":"Morten","family":"Praestegaard","sequence":"additional","affiliation":[{"name":"MC2 Therapeutics  H\u00f8rsholm Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Selmer","sequence":"additional","affiliation":[{"name":"MC2 Therapeutics  H\u00f8rsholm Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0064-8707","authenticated-orcid":false,"given":"April W.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Dan\u00f8","sequence":"additional","affiliation":[{"name":"Incentive  Holte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Dhawan","sequence":"additional","affiliation":[{"name":"Center for Dermatology Clinical Research  Fremont California USA"},{"name":"Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2435-2129","authenticated-orcid":false,"given":"Jordi","family":"Galv\u00e1n","sequence":"additional","affiliation":[{"name":"Almirall  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1721-3665","authenticated-orcid":false,"given":"Sandra E.","family":"Stallknecht","sequence":"additional","affiliation":[{"name":"Incentive  Holte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paw","family":"Trebbien","sequence":"additional","affiliation":[{"name":"MC2 Therapeutics  H\u00f8rsholm Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4026-8728","authenticated-orcid":false,"given":"Matthias","family":"Augustin","sequence":"additional","affiliation":[{"name":"University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"167","article-title":"A systematic literature review to compare quality of life in psoriasis with other chronic diseases using EQ\u20105D\u2010derived utility values","volume":"6","author":"M\u00f8ller AH","year":"2015","journal-title":"Patient Relat Outcome Meas"},{"key":"e_1_2_12_3_1","unstructured":"World Health Organization.Global report on psoriasis. 2016 [last accessed 2022 Apr 12]. Available from:https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/204417\/9789241565189_eng.pdf.psoriasis?sequence=1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17734"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2012.12.005"},{"key":"e_1_2_12_6_1","unstructured":"PinterA GreenLJ SelmerJ PraestegaardM Stein GoldL AugustinM.A pooled analysis of randomized controlled phase 3 trials investigating the efficacy and safety of a novel fixed\u2010dose calcipotriol and betamethasone dipropionate cream for the topical treatment of plaque psoriasis. Poster presented at: 30thEADV Virtual Congress; 2021 Sep 29\u2010Oct 02. Poster number 1447."},{"key":"e_1_2_12_7_1","unstructured":"Stein GoldL GreenLJ DhawanS SelmerJ Pr\u00e6stegaardM.Calcipotriol and betamethasone dipropionate cream demonstrates rapid and clinically meaningful improvement of itch associated to plaque psoriasis. Poster presented at: 30thEADV Virtual Congress; 2021 Sep 29\u2010Oct 02. Poster number 1388."},{"key":"e_1_2_12_8_1","unstructured":"PinterA ArmstrongAW Pr\u00e6stegaardM SelmerJ ReichA.Combined analysis of two head\u2010to\u2010head phase 3 trials demonstrating superior improvement of patient reported outcomes for calcipotriol and betamethasone dipropionate cream compared to gel\/topical suspension in treatment of plaque psoriasis. Poster presented at: 30thEADV Virtual Congress; 2021 Sep 29\u2010Oct 02. Poster number 1445."},{"key":"e_1_2_12_9_1","unstructured":"ReichA SelmerJ Galv\u00e1nJ TrebbienP Dan\u00f8A StallknechtSE.Quality of life and treatment satisfaction: an indirect comparison of calcipotriol and betamethasone dipropionate cream versus foam in the treatment of psoriasis vulgaris. Poster presented at: 30thEADV Virtual Congress; 2021 Sep 29\u2010Oct 02. Poster number 1382."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2018.3302"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14515"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2022.2078099"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18755","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.18755","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T07:39:36Z","timestamp":1692517176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.18755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,22]]},"references-count":11,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/jdv.18755"],"URL":"https:\/\/doi.org\/10.1111\/jdv.18755","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,22]]},"assertion":[{"value":"2022-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}