{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:45:54Z","timestamp":1791895554981,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne is a multifactorial chronic inflammatory disease of the pilosebaceous unit, where <jats:italic>Cutibacterium acnes<\/jats:italic> plays a main role. Recent papers demonstrated that specific <jats:italic>C.\u00a0acnes<\/jats:italic> phylotypes were correlated with the severity of inflammatory acne and reported a specific loss of <jats:italic>C.\u00a0acnes<\/jats:italic> phylotype diversity in this context.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this exploratory study was to evaluate the efficacy of a new dermocosmetic product containing <jats:italic>Myrtus communis<\/jats:italic> and Celastrol\u2010enriched plant cell culture extracts on <jats:italic>C.\u00a0acnes<\/jats:italic> phylotype abundance and clinical parameters in subjects with mild to moderate acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Cutibacterium acnes<\/jats:italic> phylotype diversity was evaluated by single\u2010locus sequence typing sequencing on the nonlesional areas of the forehead, that is, areas excluding inflammatory lesions (papules and pustules) on day 1 (D1) and after 56\u2009days (D57) of twice daily application of the dermocosmetic product on the whole face. Clinical efficacy on acne was also assessed by acne lesion counting and Global Evaluation Acne (GEA) score on D1 and D57.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our study confirmed the link between the presence of some <jats:italic>C.\u00a0acnes<\/jats:italic> phylotypes and acne severity. The dermocosmetic cream was linked to a positive impact on <jats:italic>C.\u00a0acnes<\/jats:italic> phylotypes: a significant decrease in pro\u2010pathogen phylotype IC and increase in nonpathogen phylotype IB were observed in the nonlesional areas of acne on D57 compared to D1. In parallel, the clinical results showed a significant decrease in inflammatory and comedonal acne lesions and a significant improvement in the acne severity according to the GEA score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed that the application of a new dermocosmetic product containing <jats:italic>M.\u00a0communis<\/jats:italic> and Celastrol\u2010enriched plant cell culture extracts was linked to a change in the <jats:italic>C.\u00a0acnes<\/jats:italic> phylotype abundance and an improvement in acne severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18792","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T16:43:41Z","timestamp":1675356221000},"page":"20-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Change in <i>Cutibacterium acnes<\/i> phylotype abundance and improvement of clinical parameters using a new 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