{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:02:08Z","timestamp":1787950928418,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne is a very common condition. Currently, there are relatively few studies available to help guidance\u2010based decisions for its long\u2010term management, especially studies with cosmetic care products. We have developed a skin care product dedicated to adult female acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evaluate the efficacy and tolerance of the test product containing <jats:italic>Myrtus communis<\/jats:italic> extract and azelaic acid compared with a light moisturizing cream (LCM) in adult females in the acne maintenance phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A clinical study was conducted as a Brazilian, multicentre, randomized, investigator\u2010blinded trial in adult females with clear or almost clear facial acne after anti\u2010acne treatment. The test group (26 subjects) applied the test product and the comparative product group (27 subjects) applied LCM. Both groups applied the products twice daily on the whole face. Subjects were evaluated every 4\u2009weeks over 16\u2009weeks. Efficacy was evaluated according to acne relapse; Investigator's Global Assessment (IGA); acne lesions counting; AcneQoL questionnaire; Subject Global change Assessment (SGA) of acne severity; and the number of Post\u2010Inflammatory Hyperpigmentation (PIH) and Post\u2010Inflammatory Erythema (PIE) lesions. Tolerance was assessed according to a 5\u2010point scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 16\u2009weeks, the number of acne relapse was more than double in the comparator compared to the test product group (eight subjects vs. three subjects respectively). There was no statistical difference in the evolution of the mean IGA from baseline between the two groups; however, 85% of subjects were assessed as clear or almost clear in the test product group and 67% in the comparative group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated the effectiveness topical application of the test product compared to LCM on acne severity in the maintenance phase of adult female acne. Efficacy results after 16\u2009weeks suggested a trend to limit acne relapses and a benefit of the test product in maintaining long\u2010term remission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18795","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T16:43:41Z","timestamp":1675356221000},"page":"26-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The usefulness of a dermocosmetic containing <i>Myrtus communis<\/i> extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator\u2010blinded comparative study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7190-8241","authenticated-orcid":false,"given":"Edileia","family":"Bagatin","sequence":"first","affiliation":[{"name":"Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1397-0076","authenticated-orcid":false,"given":"Marie Dominique","family":"Thouvenin","sequence":"additional","affiliation":[{"name":"Clinical Skin Research and Development Center, Pierre Fabre Dermo\u2010Cosm\u00e9tique  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Bacquey","sequence":"additional","affiliation":[{"name":"Clinical Skin Research and Development Center, Pierre Fabre Dermo\u2010Cosm\u00e9tique  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Baradat","sequence":"additional","affiliation":[{"name":"Clinical Skin Research and Development Center, Pierre Fabre Dermo\u2010Cosm\u00e9tique  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Lauze","sequence":"additional","affiliation":[{"name":"Clinical Skin Research and Development Center, Pierre Fabre Dermo\u2010Cosm\u00e9tique  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-3974","authenticated-orcid":false,"given":"Valerie","family":"Mengeaud","sequence":"additional","affiliation":[{"name":"Medical Department Ducray Dermatological Laboratories, Les Cauquillous  Lavaur France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana L. M.","family":"Soares","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo de S.M.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2596-9294","authenticated-orcid":false,"given":"Helio A.","family":"Miot","sequence":"additional","affiliation":[{"name":"Botucatu Medical School Universidade do Estado de Sao Paulo\/UNESP (Sao Paulo State University)  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1090-177X","authenticated-orcid":false,"given":"Marco Alexandre","family":"Rocha","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2010.2722"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00357.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S137794"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14441"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20198203"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/0128071-200809060-00003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5122"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1270955"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2015.11.016"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2007.02.001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3831\/KPI.2020.23.4.220"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199141050-00007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1657222"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354889"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12823"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14491"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13190"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-021-00586-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00633-4"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2020.4887"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18795","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.18795","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T05:43:44Z","timestamp":1692510224000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.18795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,2]]},"references-count":20,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/jdv.18795"],"URL":"https:\/\/doi.org\/10.1111\/jdv.18795","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,2]]},"assertion":[{"value":"2022-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}