{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:48:02Z","timestamp":1787078882148,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["U19 069526"],"award-info":[{"award-number":["U19 069526"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fatigue is a symptom that can negatively impact patients' quality of life. However, the relationship of AD with fatigue has not been fully studied, especially in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence of fatigue in AD patients, and whether AD severity, demographics and comorbidities are associated with increased fatigue in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional observational study was performed among 248 children with AD. Paediatric patients (ages 8\u201317\u2009years) and parents (of children ages 0\u201317\u2009years) completed a questionnaire, including demographics, history of atopic comorbidities and validated severity measures of AD, itch, pain, sleep disturbance, sleep\u2010related impairment and fatigue. AD severity was also assessed by clinician\u2010reported Eczema Area and Severity Index (EASI), Scoring AD (SCORAD) and Investigator's Global Assessment (IGA). Fatigue was assessed using Patient Reported Outcome Measurement Information System (PROMIS) Pediatric Fatigue T\u2010score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most children with AD had no (38.6%) or mild (32.1%) fatigue, with fewer having moderate (27.2%) or severe (2%) fatigue. Moderate\/severe PROMIS Pediatric fatigue T\u2010scores were increased with moderate (25.7%\/1.4%) and severe (39.3%\/5.4%) IGA vs. mild IGA (18.0%\/0.0%) and those with 5\u20136 (44.4%\/0.0%) and 7 (44.2%\/5.2%) nights of SD from eczema. Moderate\u2013severe PROMIS Pediatric Fatigue T\u2010scores were associated with history of hay fever (adjusted OR [95% Cl]: 2.803 [1.395\u20135.632]) and family income (&lt;$100,000: 3.049 [1.294\u20137.181]), but inversely with Black (0.40 [0.168\u20130.969]) and AAPI (0.285 [0.094\u20130.859]) race. In multivariable regression models controlling for demographic factors, PROMIS Pediatric Fatigue T\u2010score was significant with more severe scores for IGA, POEM, EASI, SCORAD, NRS\u2010itch, SCORAD\u2010itch, average itch in the past 7\u2009days, PROMIS Pediatric Pain severity, PROMIS Pediatric SD, PROMIS Pediatric SRI, SCORAD\u2010sleep and more frequent SD from AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fatigue is a common yet underappreciated symptom in children with AD, particularly those with moderate\u2013severe AD, and warrants more attention in clinical practice and trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18819","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T10:22:16Z","timestamp":1671618136000},"page":"763-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prevalence and associations of fatigue in childhood atopic dermatitis: A cross\u2010sectional study"],"prefix":"10.1111","volume":"37","author":[{"given":"Stephanie M.","family":"Rangel","sequence":"first","affiliation":[{"name":"School of Medicine and Health Sciences George Washington University School of Medicine and Health Sciences  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Dermatology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjani","family":"Sheth","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences George Washington University School of Medicine and Health Sciences  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alli","family":"Blumstein","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences George 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