{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:31Z","timestamp":1787015551726,"version":"build-2736575974"},"reference-count":69,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1S37621N"],"award-info":[{"award-number":["1S37621N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["T003218N"],"award-info":[{"award-number":["T003218N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Real\u2010world studies on the use of biologics in psoriasis (Pso) are increasing, but still scarce. Trough concentrations (\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>t<\/jats:sub>\n                      s) of interleukin\u201017 inhibitors (IL\u201017i) seem promising for clinical decision\u2010making, but their value in daily practice has yet to be proven.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To report on IL\u201017i effectiveness, treatment modifications and\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>t<\/jats:sub>\n                      use in our clinic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from IL\u201017i\u2010treated Pso patients followed up in the PsoPlus clinic at the Dermatology department, Ghent University Hospital, Belgium. Descriptive statistics and Kaplan\u2013Meier analysis were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 111 patients were included, counting for 134 IL\u201017i courses (secukinumab, ixekizumab, and brodalumab). Fifty\u2010five per cent of the patients were bio\u2010naive prior to IL\u201017i initiation. During maintenance, merely 97.0% and 77% achieved near\u2010complete and complete skin clearance, respectively. Major reasons for treatment modification were suboptimal response (63.0%) and safety issues (9.3%). Reported modifications were switch (25.4%), dose escalation (11.9%), dose de\u2010escalation (6.7%), treatment association (6.0%) and IL\u201017i stop (3.0%). Overall drug survival was 69.0\u00a0months, without difference between the different IL\u201017i (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.078). Ixekizumab tended to have the highest survival. Drug survival was higher in bio\u2010naive subjects compared to bio\u2010experienced subjects (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.011).\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>t<\/jats:sub>\n                      was measured in 20 patients and interpreted post hoc. In 85%, the clinical decision was in accordance with the\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>t<\/jats:sub>\n                      (e.g. substantiated need for dose escalation). For the other cases, the\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>t<\/jats:sub>\n                      would have led to another clinical decision if known at that time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This real\u2010world study showed that IL\u201017i are very effective drugs for Pso, with ixekizumab as leading biologic. Prior bio\u2010experience seemed to impact IL\u201017i drug survival. Treatment modifications were mainly performed in case of insufficient response, primarily via switch and dose escalation, and least frequently in ixekizumab patients.\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>t<\/jats:sub>\n                      might rationalize clinical decision\u2010making; however, there is need for standardized algorithms to corroborate its use.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.18827","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T09:44:15Z","timestamp":1671788655000},"page":"698-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Blocking interleukin\u201017 in psoriasis: Real\u2010world experience from the\n                    <scp>PsoPlus<\/scp>\n                    cohort"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3375-7467","authenticated-orcid":false,"given":"Lisa","family":"Schots","sequence":"first","affiliation":[{"name":"Department of Dermatology Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rani","family":"Soenen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Blanquart","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","article-title":"Systemic pharmacological treatments for chronic plaque psoriasis: a network meta\u2010analysis","volume":"1","author":"Sbidian E","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.4029"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1743811"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2021.1890683"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-020-00322-1"},{"key":"e_1_2_9_7_1","unstructured":"European Medicines Agency.Cosentyx;2015[accessed 2021 Mar 31]. 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