{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T11:55:47Z","timestamp":1794052547589,"version":"4.8.0"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Biologic treatments have been studied mainly in patients with a long\u2010term history of psoriasis and previous treatment failures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this primary analysis of the STEPIn study is to determine whether early intervention with secukinumab in patients with new\u2010onset moderate to severe plaque psoriasis is superior to standard of care treatment with narrow band ultraviolet B (nb\u2010UVB) phototherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The STEPIn study is a randomized, open\u2010label, multicentre study to investigate early intervention with 52\u2009weeks of secukinumab 300\u2009mg administered subcutaneously versus standard treatment with nb\u2010UVB phototherapy in patients with new\u2010onset (\u226412\u2009months) moderate to severe plaque psoriasis (NCT03020199). The primary and additional secondary endpoints were \u226590% improvement in Psoriasis Area and Severity Index (PASI 90) at Week 52 and Investigator's Global Assessment (IGA mod 2011) 0\/1 response at Week 52, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the secukinumab and nb\u2010UVB study arms, 77\/80 and 76\/80 randomized patients received at least one dose of study treatment, respectively. The primary endpoint was achieved: 91.1% (70\/77) of patients achieved a PASI 90 response at Week 52 in the secukinumab arm versus 42.3% (32\/76) in the nb\u2010UVB arm (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.0001, odds ratio [OR] estimate [95% confidence intervals, CI]\u00a0=\u00a016.3 [5.6, 46.9]). The additional secondary endpoint was also achieved: 85.7% of patients achieved an IGA 0\/1 response at Week 52 in the secukinumab arm versus 36.8% in the nb\u2010UVB arm (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.0001). The safety data were consistent with the safety profiles of secukinumab and nb\u2010UVB with no new or unexpected safety signals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Secukinumab was superior to nb\u2010UVB in treating patients with new\u2010onset moderate to severe plaque psoriasis. The high and sustained skin clearance observed indicates that biologic treatment for psoriasis may be more effective if used early in the disease course.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18846","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T10:33:26Z","timestamp":1673001206000},"page":"1004-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Secukinumab demonstrates superiority over narrow\u2010band ultraviolet B phototherapy in new\u2010onset moderate to severe plaque psoriasis patients: Week 52 results from the <scp>STEPIn<\/scp> study"],"prefix":"10.1111","volume":"37","author":[{"given":"Lars","family":"Iversen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2547-3440","authenticated-orcid":false,"given":"Curdin","family":"Conrad","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHUV University Hospital and University of Lausanne (UNIL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liv","family":"Eidsmo","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Unit of Rheumatology Karolinska University Hospital  Stockholm Sweden"},{"name":"Leo Foundation Skin Immunology Research Center University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9697-2557","authenticated-orcid":false,"given":"Antonio","family":"Costanzo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"Dermatology Unit IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Narbutt","sequence":"additional","affiliation":[{"name":"Dermoklinika Medical Centre  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1330-1502","authenticated-orcid":false,"given":"Andreas","family":"Pinter","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Goethe\u2010Universit\u00e4t Frankfurt am Main  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00fclli","family":"Kingo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tartu, Dermatology Clinic, Tartu University Hospital  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4604-0724","authenticated-orcid":false,"given":"Raquel","family":"Rivera\u00a0Diaz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Kolbinger","sequence":"additional","affiliation":[{"name":"Department of Autoimmunity, Transplantation &amp; Immunology Novartis Institutes for Biomedical Research  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ManikPrabhu","family":"Nanna","sequence":"additional","affiliation":[{"name":"Novartis IMI AG  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Annika","family":"Frueh","sequence":"additional","affiliation":[{"name":"Novartis IMI AG  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Jagiello","sequence":"additional","affiliation":[{"name":"Novartis IMI AG  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12589"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.07.023"},{"issue":"8","key":"e_1_2_9_4_1","first-page":"912","article-title":"Scalp psoriasis: an overview of the disease and available therapies","volume":"9","author":"Crowley J","year":"2010","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201610"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000316169"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2018.1401468"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052935"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12355"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314258"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001107"},{"issue":"8","key":"e_1_2_9_12_1","first-page":"821","article-title":"Secukinumab improves physical function in subjects with plaque psoriasis and psoriatic arthritis: results from two randomized, phase 3 trials","volume":"14","author":"Gottlieb AB","year":"2015","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12110"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60125-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.206"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.09.002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.09.010"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12404"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21594"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jvc2.63"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10991.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2014.880396"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.11.018"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.374"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.280"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3883"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3233"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700489"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh199"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60304-9"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04725-5"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21757"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107925"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.04.029"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215356"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100123"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.12.036"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2013.58"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.001"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61134-5"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.05.013"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.05.033"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.058"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14878"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17351"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16124"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11097"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1882-2"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16180"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14979"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0176-6"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1671577"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16632"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.06.035"},{"issue":"7","key":"e_1_2_9_55_1","first-page":"737","article-title":"The importance of early treatment in psoriasis and management of disease progression","volume":"17","author":"Kerdel F","year":"2018","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1159\/000251595"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.18846","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.18846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T18:26:24Z","timestamp":1692642384000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.18846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,27]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/jdv.18846"],"URL":"https:\/\/doi.org\/10.1111\/jdv.18846","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,27]]},"assertion":[{"value":"2022-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}