{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:34:26Z","timestamp":1793637266490,"version":"4.5.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T00:00:00Z","timestamp":1674259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evaluation of effectiveness and safety of new systemic treatments for atopic dermatitis (AD) after approval is important. There are few published data exceeding 52\u2010week therapy with dupilumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine the safety, effectiveness and drug survival of dupilumab in a Danish nationwide cohort with moderate\u2010to\u2010severe AD up to 104\u2009weeks exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 347 adult patients with AD who were treated with dupilumab and registered in the SCRATCH registry during 2017\u20132022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At all visits, we observed improvement in AD severity measured by Eczema Area and Severity Index (EASI) [median (IQR)]. EASI score at baseline was 18.0 (10.6\u201325.2), at week 4: 6.5 (3.5\u201311.6), at week 16: 3.7 (1.2\u20136.2), at week 52: 2.0 (0.8\u20133.6), at week 104: 1.7 (0.8\u20133.8). While drug survival was high (week 52: 90%; week 104: 86%), AD in the head\u2010and\u2010neck area remained present in most patients at high levels; proportion with head\u2010and\u2010neck AD at baseline was 76% and 68% at week 104. 35% of patients reported any AE. Conjunctivitis was the most frequent (25% of all patients) and median time to first registration of conjunctivitis was 201\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While 2\u2010year drug survival was 86%, dupilumab was unable to effectively treat AD in the head\u2010and\u2010neck area, and conjunctivitis was found in 25% of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.18849","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T05:49:36Z","timestamp":1672984176000},"page":"1046-1055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["A nationwide 104\u2009weeks real\u2010world study of dupilumab in adults with atopic dermatitis: Ineffectiveness in head\u2010and\u2010neck dermatitis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3192-6135","authenticated-orcid":false,"given":"Ida","family":"Vittrup","sequence":"first","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-1674","authenticated-orcid":false,"given":"Niels Steen","family":"Krogh","sequence":"additional","affiliation":[{"name":"ZiteLab ApS  Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Hedegaard Pliess","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8925-4722","authenticated-orcid":false,"given":"Jesper","family":"Elberling","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-9680","authenticated-orcid":false,"given":"Lone","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5324-1591","authenticated-orcid":false,"given":"Kristina Sophie","family":"Ibler","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital, University of Copenhagen  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-2540","authenticated-orcid":false,"given":"Gregor B. E.","family":"Jemec","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital, University of Copenhagen  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8710-0829","authenticated-orcid":false,"given":"Charlotte G.","family":"Mortz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2502-3551","authenticated-orcid":false,"given":"Rasmus Overgaard","family":"Bach","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense University Hospital  Odense 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CarlsenB ThomsenSF HolmE M\u00f8rtzC VestergaardC.Udredning og behandling af patienter med atopisk dermatitis [Diagnosis and treatment of patients with atopic dermatitis In Danish]. 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